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Changes in acetylcholine receptor expression : neuromuscular junction morphology and associated myonuclei in BALB/C mice following muscle contusion injury
(Stellenbosch : Stellenbosch University, 2015-03)
ENGLISH ABSTRACT: Contusion injuries cause significant muscle damage, that effects skeletal muscle in its entirety, including the innervating motorneuron and the myofibre’s neuromuscular junction (NMJ). Upon injury, the ...
Elucidating the underlying mechanisms of benfotiamine-induced cardioprotection
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Context: Cardiovascular diseases are the leading cause of death globally. Myocardial infarction is responsible for the highest number of deaths due to cardiovascular disease.
Objective: We have previously ...
The effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the non-oxidative pathways of glucose metabolism
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: While antiretroviral therapy decreases HIV/AIDS morbidity and mortality, long-term treatment results in insulin resistance and cardiovascular diseases. A possible cause of such adverse effects may be an ...
Circadian rhythms as novel chemotherapeutic strategies for breast cancer
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction: Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. ...
HIV-1 associated neuroinflammation : effects of two complimentary medicines illustrated in an in vitro model of the blood-brain barrier
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Background: Neuroinflammation is central to the aetiology of HIV-associated neurocognitive disorders (HAND) that are prevalent in late stage AIDS. ARV treatments are rolled out relatively late in the ...
Modulation of oxidative stress and inflammation using a grape seed derived polyphenol
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Oxidative stress and inflammation are intricately interlinked, especially in the context of ageing/accelerated ageing, as well as several chronic disease states, where they are implicated as aetiological ...
Investigation of myostatin and relevant regulators during muscle regeneration after an acute bout of eccentric exercise
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: The aim of this study was to investigate the powerful muscle regulator, myostatin, and its regulators in response to an acute bout of plyometric training. The participants were recruited and screened by ...
Proteasome Inhibitors : a novel therapy that blunt hyperglycemia-induced cardiac contractile dysfunction
(Stellenbosch : Stellenbosch University, 2015-04)
ENGLISH ABSTRACT: Diabetes is considered a major threat to human health in both developed and developing nations. Cardiovascular disease which is common in diabetic patients has increased the overall disease affliction. ...
The (un)SAFE and RISK(y) sides of doxorubicin-induced cardiotoxicity
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction
The discovery of Doxorubicin in the 1960s has drastically improved the survival rates of cancer
patients, however, its success is limited by dose-dependent cardiotoxicity. While much of the ...
Association between the metabolic syndrome and cancer risk : the potential role of fatty acids on body composition
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Background: Sub-Sahara Africa is experiencing an epidemiological transition with an increasing burden of non-communicable diseases (NCDs) including obesity, hypertension, insulin resistance (IR) and ...