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Elucidating the underlying mechanisms of benfotiamine-induced cardioprotection
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Context: Cardiovascular diseases are the leading cause of death globally. Myocardial infarction is responsible for the highest number of deaths due to cardiovascular disease.
Objective: We have previously ...
Circadian rhythms as novel chemotherapeutic strategies for breast cancer
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction: Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. ...
HIV-1 associated neuroinflammation : effects of two complimentary medicines illustrated in an in vitro model of the blood-brain barrier
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Background: Neuroinflammation is central to the aetiology of HIV-associated neurocognitive disorders (HAND) that are prevalent in late stage AIDS. ARV treatments are rolled out relatively late in the ...
Investigation of myostatin and relevant regulators during muscle regeneration after an acute bout of eccentric exercise
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: The aim of this study was to investigate the powerful muscle regulator, myostatin, and its regulators in response to an acute bout of plyometric training. The participants were recruited and screened by ...
The (un)SAFE and RISK(y) sides of doxorubicin-induced cardiotoxicity
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction
The discovery of Doxorubicin in the 1960s has drastically improved the survival rates of cancer
patients, however, its success is limited by dose-dependent cardiotoxicity. While much of the ...
Elucidating the role of WDR47 in regulating neuronal migration, autophagy and tubulin dynamics
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction Normal cerebral cortex development depends on extensive neuronal migration during
embryogenesis, permitting the formation of accurate synaptic circuits and a highly ordered
laminar neocortex. ...