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Deubiquitination : does the answer to cardiotoxicity lie within the ubiquitin proteasome pathway
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Introduction: Cardiotoxicity, a complication that arises from anthracycline use is one that has confounded scientists for decades. Attempts have been made to attenuate the development of this condition ...
Elucidation of molecular mechanisms that may contribute to polyphenol-induced effects on neutrophil chemokinesis
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Grape-derived products are high in polyphenols and are known to have anti-oxidant and anti-inflammatory effects. In vivo studies in the context of muscle injury-induced inflammation have proven grape ...
Exosome dynamics and changes in a selection of their microRNA cargo in response to an acute bout of eccentrically-biased exercise in healthy human volunteers
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Background: Extracellular vesicles (EVs) are nanoscale (30 to 1000 nm diameter) mediators of intercellular information transfer, shuttling diverse cargos including functional nucleic acids, proteins and ...
Are early proteomic and metabolic changes induced by long-term sugar-sweetened beverage consumption the key to unlocking the cardio-metabolic pandemic?
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: INTRODUCTION: Cardio-metabolic diseases (e.g. type 2 diabetes mellitus) are a major cause of
mortality worldwide. The incidence of cardio-metabolic diseases continues to increase, especially in low and ...
The Dose and Time Dependent Effects of HGF on Myf-5, MyoD and miR-31 Expression in Quiescent Primary Human Myoblasts
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Satellite cells are progenitor cells that persist in adult muscle in a quiescent state. Upon injury, growth or hypertrophy, satellite cells become activated, proliferate and differentiate into myoblasts. ...