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Elucidating the underlying mechanisms of benfotiamine-induced cardioprotection
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Context: Cardiovascular diseases are the leading cause of death globally. Myocardial infarction is responsible for the highest number of deaths due to cardiovascular disease.
Objective: We have previously ...
The effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the non-oxidative pathways of glucose metabolism
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: While antiretroviral therapy decreases HIV/AIDS morbidity and mortality, long-term treatment results in insulin resistance and cardiovascular diseases. A possible cause of such adverse effects may be an ...
Circadian rhythms as novel chemotherapeutic strategies for breast cancer
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction: Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. ...
HIV-1 associated neuroinflammation : effects of two complimentary medicines illustrated in an in vitro model of the blood-brain barrier
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Background: Neuroinflammation is central to the aetiology of HIV-associated neurocognitive disorders (HAND) that are prevalent in late stage AIDS. ARV treatments are rolled out relatively late in the ...
Investigation of myostatin and relevant regulators during muscle regeneration after an acute bout of eccentric exercise
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: The aim of this study was to investigate the powerful muscle regulator, myostatin, and its regulators in response to an acute bout of plyometric training. The participants were recruited and screened by ...
The (un)SAFE and RISK(y) sides of doxorubicin-induced cardiotoxicity
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction
The discovery of Doxorubicin in the 1960s has drastically improved the survival rates of cancer
patients, however, its success is limited by dose-dependent cardiotoxicity. While much of the ...
Elucidating the role of WDR47 in regulating neuronal migration, autophagy and tubulin dynamics
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction Normal cerebral cortex development depends on extensive neuronal migration during
embryogenesis, permitting the formation of accurate synaptic circuits and a highly ordered
laminar neocortex. ...
Establishing a rodent model of long-term consumption of sugar-sweetened beverages
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction- Cardiovascular complications contribute dramatically to morbidity and mortality incidence amongst individuals who have developed type 2 diabetes (T2D), with myocardial insulin resistance ...
Anthropometric characteristics and changes with HIV and ART in a randomly selected population in the Drakenstein region Western Cape Province
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Background - Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIVpositive
individuals. Since there are concerns regarding HAART-mediated onset of ...