Now showing items 1-4 of 4
The effect of androgenic anabolic steroids on the susceptibility of the rat heart to ischaemia and reperfusion injury
(Stellenbosch : Stellenbosch University, 2002-12)
ENGLISH ABSTRACT: Background: Athletes use androgenic anabolic steroids (AAS) to enhance their physical performance. The abuse of AAS is however associated with a host of side effects including sudden death due to cardiac ...
Signalling mechanisms involved in TNF-α mediated cytoprotection during ischaemic injury in a C2C12 muscle cell line
(Stellenbosch : University of Stellenbosch, 2006-12)
ENGLISH ABSTRACT: Both, the cytokine Tumor Necrosis Factor-α (TNF-α) and the enzyme cytosolic phospholipase A2 (cPLA2) are crucial driving forces in mediating the cellular inflammatory response and are involved in ischaemic ...
Acute simulated hypoxia and ischemia in cultured C2C12 myotubes : decreased phosphatidylinositol 3-kinase (PI3K)/Akt activity and its consequences for cell survival
(Stellenbosch : Stellenbosch University, 2008-12)
Cells are equipped with an array of adaptive mechanisms to contest the undesirable effects of ischemia and the associated hypoxia. Indeed, many studies have suggested that there is an increase in the PI3K/Akt pathway ...
The signaling pathways involved in the cardioprotection offered by insulin to the global low flow ischaemic/reperfused myocardium
(Stellenbosch : Stellenbosch University, 2001-12)
ENGLISH ABSTRACT: Introduction: It is well documented that insulin offers cardioprotection under ischaemic stress. In the past it was believed that the protective effects of insulin, such as the (a) recruitment of glucose ...