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Investigating the effects of diet-induced obesity on acute Doxorubicin-induced cardiotoxicity in a tumour-bearing model
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Introduction: Obesity is a well-known global pandemic that is fundamentally caused by an energy imbalance between calories consumed and calories expended. A major consequence to obesity are metabolic ...
Potential for modulation of cancer-associated oxidative stress : an in vitro investigation
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: While cancer is a chronic, complex disease associated with a multitude of steps in its initiation and progression, all cancers generally have similar underlying maladaptive physiological mechanisms which ...
Dynamic interactions between skeletal muscle and breast cancer cells following chemotherapeutic treatment
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Background: Breast cancer is the most common cancer found among women of South
Africa with the prominent effective form of treatment being chemotherapy. Many cancer
patients receiving chemotherapeutic ...
A matter of life or death : autophagy in the context of prolonged doxorubicin therapy
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Introduction
Doxorubicin (DOX) is an effective treatment against a variety of cancers, and thus remains a commonly used chemotherapeutic drug. The chief side effect of DOX treatment is cardiotoxicity. ...
The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Introduction: Breast cancer is frequently diagnosed in women in both developed and developing countries and poses a major health problem throughout the world. The current standard treatment for breast ...
The role of lipoteichoic acid on amyloidogenesis and its effect on erythrocytes and platelets
(Stellenbosch : Stellenbosch University, 2019-12)
ENGLISH ABSTRACT: Hypercoagulation and amyloidogenesis are commonly known as hallmarks for inflammation. Hypercoagulation and amyloidogenesis are linked to quite a few communicable and non-communicable ailments such as ...
Investigating the amyloidogenic potential of serum amyloid a in type ii diabetes mellitus
(Stellenbosch : Stellenbosch University, 2019-12)
ENGLISH ABSTRACT: Introduction: Type II Diabetes Mellitus (T2DM) is a non-communicable disease associated with chronic low-grade inflammation and persistent activation of the acute phase response (APR). Serum amyloid A ...
The comparison between two high-intensity interval training protocols on skeletal muscle and satellite cell dynamics
(Stellenbosch : Stellenbosch University, 2019-03)
ENGLISH ABSTRACT: Introduction: High intensity interval training (HIIT) interventions are popularly used by endurance athletes to increase muscle strength, peak speed and aerobic capacity. Running involves the use of both ...
Neuromuscular junction endplate morphology, acetylcholine receptor aggregation and accessory protein co-localisation during regeneration of a skeletal muscle crush injury
(Stellenbosch : Stellenbosch University, 2019-03)
ENGLISH ABSTRACT: At the neuromuscular junction (NMJ), peripheral nerves innervate the skeletal muscle to relay neural
transmission. The acetylcholine receptors (AChRs) are located on the post-synaptic membrane and ...