Now showing items 1-4 of 4
Elucidating the role of WDR47 in regulating neuronal migration, autophagy and tubulin dynamics
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction Normal cerebral cortex development depends on extensive neuronal migration during embryogenesis, permitting the formation of accurate synaptic circuits and a highly ordered laminar neocortex. ...
The role of MKP-1 in autophagy, apoptosis and necrosis during ischaemia/reperfusion injury in the heart
ENGLISH ABSTRACT: Ischaemic heart disease is a leading cause of death worldwide and is also largely contributing to deaths in Africa. Better treatment or even prevention of ischaemia/reperfusion injury in the heart, ...
The relationship between HIF-1α and autophagy activity in the hypoxic environment of breast cancer
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Introduction: Among the cancers that afflict females world-wide, neoplastic disease of breast tissue is the most frequently diagnosed form and the leading cause of cancer-related death. Conventional ...
A matter of life or death : autophagy in the context of prolonged doxorubicin therapy
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Introduction Doxorubicin (DOX) is an effective treatment against a variety of cancers, and thus remains a commonly used chemotherapeutic drug. The chief side effect of DOX treatment is cardiotoxicity. ...