SUNScholar
⇒
Faculty of Science
⇒
Department of Physiological Sciences
⇒
Masters Degrees (Physiological Sciences)
⇒
Browsing by Subject

Subject

Now showing items 1-4 of 4

Does the hexosamine biosynthetic pathway play a role in mediating the beneficial effects of oleic acid in the heart?

Harris, E. R. (Eurinah Roberta) (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Background:Obesity is a growing global burden; current studies have projected the prevalence of obese / overweight individuals to increase to ~1.35 billion by 2030. A number of factors contribute to ...
Exploring underlying mechanisms driving the onset of stress-induced insulin resistance

Otto, Delita (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic ...
Increased flux through the hexosamine biosynthetic pathway leads to the induction of acetol-CoA caboxylase gene expression in the heart

Imbriolo, Jamie (Stellenbosch : Stellenbosch University, 2008-03)

ENGLISH ABSTRACT: Gene expression of the cardiac isoform of acetyl-CoA carboxylase (ACCb) is induced in a glucose-dependent manner. ACCb produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid uptake. Previous ...
Increased hexosamine biosynthetic pathway flux impairs myocardial GLUT4 translocation

Williams, Gordon (Stellenbosch : University of Stellenbosch, 2009-03)

Aims and Background: According to the World Health Organization type 2 diabetes will constitute a major global burden of disease within the next few decades. In agreement, reports show that rapid urbanization and lifestyle ...