Now showing items 1-10 of 24
The mycosins, a family of secreted subtilisin-like serine proteases associated with the immunologically-important ESAT-6 gene clusters of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2002-12)
ENGLISH ABSTRACT: Pathogenic organisms frequently utilize proteases to perform specific functions related to virulence. There is little information regarding the role of proteolysis in Mycobacterium tuberculosis and no ...
Mycobacterium tuberculosis : genetic and phenotypic comparison
(Stellenbosch : Stellenbosch University, 2002-03)
ENGLISH ABSTRACT: This study exploits the Mycobacterium tuberculosis H37Rv genome sequence data in the context of M. tuberculosis clinical isolates, to elucidate genetic variation, and examine the phenotypic and molecular ...
The search for the PFHBI gene : refining the target area and identification and analysis of candidate gene transcripts
(Stellenbosch : Stellenbosch University, 2004-12)
ENGLISH ABSTRACT: Progressive familial heart block I (PFHBI) is an inherited autosomal dominant cardiac conduction disorder which segregates in a large South African (SA) pedigree, two smaller SA families and a Lebanese ...
The characterisation of N-Acetyltransferase (NAT) in Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2005-03)
ENGLISH ABSTRACT: A gene coding for Arylaminie N-acetyltransferase (NAT) has been found in Mycobacterium tuberculosis, the casual agent of tuberculosis (TB). N-acetyltransferase acetylates and inactivates isoniazid (INH), ...
Application of spoligotyping in the understanding of the dynamics of Mycobacterium tuberculosis strains in high incidence communities
(University of Stellenbosch. Faculty of Health Sciences. Dept. of Biomedical Sciences., 2007-03)
Tuberculosis (TB) is a global health problem and demands rigorous control management efforts. A dramatic increase in the acquisition and spread of drug resistant TB globally has been observed in recent years. A grim picture ...
The investigation of peripheral blood cellular immune responses during infection with Mycobacterium Tuberculosis
(Stellenbosch : University of Stellenbosch, 2007-03)
Despite the ongoing global tuberculosis (TB) problem and extensive research into protective immunity against this intracellular pathogen, mechanisms of protective immunity against Mycobacterium tuberculosis (Mtb) in ...
Immune parameters as biomarkers of Mycobacterium tuberculosis sterilization during anti-tuberculosis treatment
(Stellenbosch : Stellenbosch University, 2008-03)
ENGLISH ABSTRACT: Setting Study conducted in Tygerberg, Cape Town in South Africa. Hypothesis Host biomarkers associated with the antimycobacterial immune response during active infection with M. tuberculosis and during ...
Resistance to first line anti-TB drugs by gene mutation and gene modulation
(Stellenbosch : University of Stellenbosch, 2009-03)
An investigation of myosin binding protein C mutations in South Africa and a search for ligands binding to myosin binding protein C
(Stellenbosch : University of Stellenbosch, 2004-12)
ENGLISH ABSTRACT: Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited primary cardiac disease. The primary features of HCM are left ventricular hypertrophy, myocardial disarray, fibrosis and an increased ...
Understanding the mechanisms of drug resistance in enhancing rapid molecular detection of drug resistance in Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2007-12)
One of the aims of direct observed therapy strategy implemented by the World Health Organization was to prevent the development of drug resistant tuberculosis. However, in recent years a dramatic increase and spread in ...