SUNScholar
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Faculty of Medicine and Health Sciences
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Department of Biomedical Sciences
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Molecular Biology and Human Genetics
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Doctoral Degrees (Molecular Biology and Human Genetics)

Doctoral Degrees (Molecular Biology and Human Genetics)

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Recent Submissions

The development of a novel fluorescentmarker phage technology system for the early diagnosis of tuberculosis disease

Van der Merwe, Ruben Gerhard (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ...
Pharmacogenetics of Arylamine N-acetyltransferase genes in South African populations

Werely, Cedric J. (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Tuberculosis (TB) has been declared a global health emergency by the World Health Organisation, and consequently there is an urgency to develop improved methods of diagnosis and treatment. Despite the ...
Functional and genetic study of M. tuberculosis glutamine synthetase (GS) and other factors possibly involved in GS metabolism

Hayward, Don (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: Sequence analysis showed that the essential glnA1 gene of Mycobacterium tuberculosis might be closely related to an actinomycetes progenitor sequence and that this sequence may have undergone duplication ...
Molecular genetic strategies to identify Obsessive-compulsive disorder (OCD) and schizophrenia candidate genes in a South African sub-population group

Kinnear, C. J. (Craig John) (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: Obsessive-compulsive disorder is a severe, debilitating psychiatric disorder for which the underlying molecular aetiology still remains unclear. Evidence from family studies have suggested that OCD may ...
Immune parameters as biomarkers of Mycobacterium tuberculosis sterilization during anti-tuberculosis treatment

Djoba Siawaya, Joel Fleury (Stellenbosch : Stellenbosch University, 2008-03)

ENGLISH ABSTRACT: Setting Study conducted in Tygerberg, Cape Town in South Africa. Hypothesis Host biomarkers associated with the antimycobacterial immune response during active infection with M. tuberculosis and during ...
Characterization of the interaction between acetylcholinesterase and laminin : a template for discovering redundancy

Swart, Chrisna (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Apart from its primary function in the synaptic hydrolysis of acetylcholine, acetylcholinesterase (AChE) has been shown through in vitro demonstrations to be able to promote various non-cholinergic ...
Regulators of dormancy/viability of Mycobacterium tuberculosis inside the human macrophages

Botha, Maria Magdalena (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: The investigation was aimed to improve the understanding of the binding interactions between DevS and DevR that are implicated in the regulation of the dormancy response in Mycobacterium tuberculosis. ...
Investigating ligands of cardiac Myosin-Binding Protein C (cMyBPC) as potential regulators of contractility and modifiers of hypertrophy.

Swanepoel, C. C. A. (Stellenbosch : Stellenbosch University, 2011-12)

ENGLISH ABSTRACT: The regulation of cardiac contractility is dependent on cooperative interaction between the thick and thin filaments, as well as their accessory proteins, within the cardiac sarcomere. Alteration in cardiac ...
Nitrogen metabolism and the regulation thereof in Mycobacterium smegmatis

Kirsten, Catriona Jane (Stellenbosch : University of Stellenbosch, 2011-12)

ENGLISH ABSTRACT: The nitrogen metabolic pathway is essential for growth and survival of all living organisms including prokaryotes. Certain components of the pathway, such as the enzyme glutamine synthetase (GS), have ...
A candidate and novel gene search to identify the PFHBII-causative gene

Fernandez, Pedro (Pedro Wallace) (Stellenbosch : University of Stellenbosch, 2004-12)

ENGLISH ABSTRACT: Heart failure due to cardiomyopathy or cardiac conduction disease is a major cause of mortality and morbidity in both developed and developing countries. Although defined as separate clinical entities, ...
An investigation of myosin binding protein C mutations in South Africa and a search for ligands binding to myosin binding protein C

De Lange, W. J. (Willem Jacobus) (Stellenbosch : University of Stellenbosch, 2004-12)

ENGLISH ABSTRACT: Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited primary cardiac disease. The primary features of HCM are left ventricular hypertrophy, myocardial disarray, fibrosis and an increased ...
The molecular epidemiology of mycobacterium tuberculosis : role in understanding disease dynamics in high prevalence settings in Southern Africa region

Chihota, Violet (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: The tuberculosis (TB) incidence has increased in Southern Africa and the situation is worsened by the emergence of drug-resistant Mycobacterium tuberculosis strains. Molecular biological techniques have ...
Fumonisin exposure biomarkers in humans consuming maize staple diets

Van der Westhuizen, Liana (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: Fumonisins are carcinogenic mycotoxins which occur world-wide in maize and maize-based products intended for human consumption. Consumption of fumonisin contaminated maize as a staple diet has been ...
Investigation into genotypic diagnostics for mycobacterium tuberculosis

Hoek, Kim Gilberte Pauline (Stellenbosch : Stellenbosch University, 2010-12)

ENGLISH ABSTRACT: Diagnostic delay is regarded as a major contributor to the continuous rise in tuberculosis (TB) cases and the emergence and transmission of multidrug-resistant tuberculosis (MDR-TB) and extensively drug ...
Investigations of the role of myomegalin in the phosphorylation of cardiac myosin binding protein C

Uys, Gerrida Mathilda (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac muscle disorder worldwide. The disease is characterized by extreme variability in the amount of hypertrophy that develops in different ...

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