Doctoral Degrees (Molecular Biology and Human Genetics)
Recent Submissions
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Mapping of the distribution of Mycobacterium bovis strains involved in bovine tuberculosis in Mozambique
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Bovine tuberculosis (BTB), caused by bacteria of the Mycobacterium tuberculosis complex is reported to cause economic and public health negative impact in countries where it is prevalent. The control ...
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Differential inhibition of adenylylated and deadenylylated Mycobacteriun tuberculosis glutamine synthetase by ATP scaffold-based inhibitors
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Please refer to full text for abstract
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Identification of parkin interactions: implications for Parkinson’s disease
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Parkinson’s disease (PD) is a progressive and debilitating neurodegenerative disorder, characterized by a distinct motor phenotype and the selective loss of dopaminergic neurons in the substantia nigra. ...
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The role of novel protein-protein interactions in the function and mechanism of the sarcomeric protein, myosin binding protein H (MyBPH)
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality, and is a feature of common diseases, such as hypertension and diabetes. It is therefore vital to ...
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Host genetic factors in susceptibility to mycobacterial disease in the African buffalo, Syncerus caffer.
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Bovine tuberculosis (BTB) is a chronic, infectious disease found in domestic livestock and wildlife, and has serious biodiversity, economic and public health implications. African buffalo act as a wildlife ...
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A phylogenomic- and proteomic investigation into the evolution and biological characteristics of the members of the group 2 Latin-American Mediterranean (LAM) genotype of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis (TB), a disease that affects millions of people world-wide. The species M. tuberculosis consists of a large number of ...
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Investigation of the activity of sulfonamide anti-bacterial drugs in Mycobacterium tuberculosis and the role of oxidative stress on the efficacy of these drugs
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Tuberculosis (TB) has become a global health epidemic affecting millions of people worldwide with a high incidence in third-world countries. The emergence of multi-drug and extremely-drug resistant M. ...
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The role of the major histocompatibility complex and the Leukocyte receptor complex genes in susceptibility to tuberculosis in a South African population
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Tuberculosis (TB) disease results in approximately 2 million deaths annually and is the leading cause of death due to a single infectious agent. Previous studies have indicated that host genetics play ...
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Molecular and functional characterisation of Long QT Syndrome causing genes
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Ventricular arrhythmias are the most important cause of sudden cardiac death (SCD) among adults living in industrialised nations. Genetic factors have substantial effects in determining population-based ...
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Investigation of genetic variation contributing to antipsychotic treatment response in a South African first episode schizophrenia cohort
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Schizophrenia is a debilitating disorder that occurs the world over. Although antipsychotics are largely effective in treating the positive symptoms of schizophrenia, the outcomes are non-optimal in ...
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The evolution of the Mycobacterium tuberculosis proteome in response to the development of drug resistance
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: This study is the first of its kind to highlight the importance of using the latest state of the art technology available in the field of proteomics as a complementary tool to characterize the proteome ...
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Identification of mechanisms regulating the intra cellular concentration of rifampicin in Mycobacterium Tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Rifampicin resistance in clinical isolates of Mycobacterium tuberculosis develops through selection of bacterial variants harbouring mutations in the rpoB gene. These mutations infer a fitness-cost in the ...
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Understanding the evolution and function of the mycobacterial Type VII ESX secretion systems (T7SSs) and their substrates
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, contains five copies of the ESAT-6 gene cluster, each encoding a dedicated ESX protein secretion system which has been defined as ...
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Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship ...
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Renin-angiotensin-aldosterone system genes and the complex hypertrophic phenotype of hypertrophic cardiomyopathy
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is a strong independent predictor of cardiovascular morbidity and mortality, while its regression is associated with an improved clinical prognosis. It is, therefore, ...
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The development of a novel fluorescentmarker phage technology system for the early diagnosis of tuberculosis disease
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ...
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Gene expression and cytokine pattern of pulmonary tuberculosis patients and their contacts in Ethiopia
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The immune response against M. tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics ...
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Pharmacogenetics of Arylamine N-acetyltransferase genes in South African populations
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Tuberculosis (TB) has been declared a global health emergency by the World Health Organisation, and consequently there is an urgency to develop improved methods of diagnosis and treatment. Despite the ...
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Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the ESX-1 secretion system. ...
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Elucidation of the mode of action of a furanone based antituberculosis compound
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: The prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has been increasing to alarming levels globally. This has been exacerbated by tuberculosis ...
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A multi-disciplinary approach towards elucidating the genetics of multiple sclerosis
(Stellenbosch : Stellenbosch University, 2003-03)ENGLISH ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Current knowledge suggests that MS is associated with autoimmunity and that infectious agents and hereditary ...
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The mycosins, a family of secreted subtilisin-like serine proteases associated with the immunologically-important ESAT-6 gene clusters of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2002-12)ENGLISH ABSTRACT: Pathogenic organisms frequently utilize proteases to perform specific functions related to virulence. There is little information regarding the role of proteolysis in Mycobacterium tuberculosis and no ...
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Role of cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) and p38 mitogen activated protein kinase (p38 MAPK) in preconditioning of the ischaemic myocardium
(Stellenbosch : Stellenbosch University, 2002-12)ENGLISH ABSTRACT: Ischaemic preconditioning (PC) is the phenomenon whereby a short episode of coronary occlusion followed by reperfusion protects the myocardium against a subsequent period of prolonged (also called index ...
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Mycobacterium tuberculosis : genetic and phenotypic comparison
(Stellenbosch : Stellenbosch University, 2002-03)ENGLISH ABSTRACT: This study exploits the Mycobacterium tuberculosis H37Rv genome sequence data in the context of M. tuberculosis clinical isolates, to elucidate genetic variation, and examine the phenotypic and molecular ...
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Molecular investigation into regulatory regions of the LDLR gene involved in lipoprotein metabolism
(Stellenbosch : Stellenbosch University, 2001)ENGLISH ABSTRACT: The advent of the new millennium saw the complete sequencing of the entire human genome. Only approximately 30 000 genes, much less than was initially predicted, have been identified to be responsible ...
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The search for the PFHBI gene : refining the target area and identification and analysis of candidate gene transcripts
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: Progressive familial heart block I (PFHBI) is an inherited autosomal dominant cardiac conduction disorder which segregates in a large South African (SA) pedigree, two smaller SA families and a Lebanese ...
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Immune responses in a community with a high incidence of tuberculosis
(Stellenbosch : Stellenbosch University, 2004-03)ENGLISH ABSTRACT: It is estimated that about one third of the world's population is infected with Mycobacterium tuberculosis (M. tuberculosis). Of those infected, only 10 % will develop disease of which 3-5 % will relapse ...
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Clinical and laboratory investigation of latex allergy in healthcare workers
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: Healthcare workers (HCWs) wear latex gloves to protect themselves and their patients against the transmission of microbial, viral and bloodborne diseases. These individuals are primarily exposed to ...
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A candidate and novel gene search to identify the PFHBII-causative gene
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: Heart failure due to cardiomyopathy or cardiac conduction disease is a major cause of mortality and morbidity in both developed and developing countries. Although defined as separate clinical entities, ...
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Functional and genetic study of M. tuberculosis glutamine synthetase (GS) and other factors possibly involved in GS metabolism
(Stellenbosch : Stellenbosch University, 2007-12)ENGLISH ABSTRACT: Sequence analysis showed that the essential glnA1 gene of Mycobacterium tuberculosis might be closely related to an actinomycetes progenitor sequence and that this sequence may have undergone duplication ...
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