SUNScholar
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Faculty of Medicine and Health Sciences
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Department of Biomedical Sciences
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Molecular Biology and Human Genetics
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Doctoral Degrees (Molecular Biology and Human Genetics)

Doctoral Degrees (Molecular Biology and Human Genetics)

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Recent Submissions

The evolution of the Mycobacterium tuberculosis proteome in response to the development of drug resistance

Fortuin, Suereta (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: This study is the first of its kind to highlight the importance of using the latest state of the art technology available in the field of proteomics as a complementary tool to characterize the proteome ...
Identification of mechanisms regulating the intra cellular concentration of rifampicin in Mycobacterium Tuberculosis

De Vos, Margaretha (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: Rifampicin resistance in clinical isolates of Mycobacterium tuberculosis develops through selection of bacterial variants harbouring mutations in the rpoB gene. These mutations infer a fitness-cost in the ...
Understanding the evolution and function of the mycobacterial Type VII ESX secretion systems (T7SSs) and their substrates

Newton-Foot, Mae (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, contains five copies of the ESAT-6 gene cluster, each encoding a dedicated ESX protein secretion system which has been defined as ...
Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis

Barnard, Marinus (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship ...
Renin-angiotensin-aldosterone system genes and the complex hypertrophic phenotype of hypertrophic cardiomyopathy

Carstens, Nadia (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is a strong independent predictor of cardiovascular morbidity and mortality, while its regression is associated with an improved clinical prognosis. It is, therefore, ...
The development of a novel fluorescentmarker phage technology system for the early diagnosis of tuberculosis disease

Van der Merwe, Ruben Gerhard (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ...
Gene expression and cytokine pattern of pulmonary tuberculosis patients and their contacts in Ethiopia

Bekele, Adane Mihret (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: The immune response against M. tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics ...
Pharmacogenetics of Arylamine N-acetyltransferase genes in South African populations

Werely, Cedric J. (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Tuberculosis (TB) has been declared a global health emergency by the World Health Organisation, and consequently there is an urgency to develop improved methods of diagnosis and treatment. Despite the ...
Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens

Bruiners, Natalie (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the ESX-1 secretion system. ...
Elucidation of the mode of action of a furanone based antituberculosis compound

Ngwane, Andile Happyboy (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: The prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has been increasing to alarming levels globally. This has been exacerbated by tuberculosis ...
A candidate and novel gene search to identify the PFHBII-causative gene

Fernandez, Pedro (Stellenbosch : Stellenbosch University, 2004-12)

ENGLISH ABSTRACT: Heart failure due to cardiomyopathy or cardiac conduction disease is a major cause of mortality and morbidity in both developed and developing countries. Although defined as separate clinical entities, ...
Functional and genetic study of M. tuberculosis glutamine synthetase (GS) and other factors possibly involved in GS metabolism

Hayward, Don (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: Sequence analysis showed that the essential glnA1 gene of Mycobacterium tuberculosis might be closely related to an actinomycetes progenitor sequence and that this sequence may have undergone duplication ...
Molecular genetic strategies to identify Obsessive-compulsive disorder (OCD) and schizophrenia candidate genes in a South African sub-population group

Kinnear, C. J. (Craig John) (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: Obsessive-compulsive disorder is a severe, debilitating psychiatric disorder for which the underlying molecular aetiology still remains unclear. Evidence from family studies have suggested that OCD may ...
Immune parameters as biomarkers of Mycobacterium tuberculosis sterilization during anti-tuberculosis treatment

Djoba Siawaya, Joel Fleury (Stellenbosch : Stellenbosch University, 2008-03)

ENGLISH ABSTRACT: Setting Study conducted in Tygerberg, Cape Town in South Africa. Hypothesis Host biomarkers associated with the antimycobacterial immune response during active infection with M. tuberculosis and during ...
Characterization of the interaction between acetylcholinesterase and laminin : a template for discovering redundancy

Swart, Chrisna (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Apart from its primary function in the synaptic hydrolysis of acetylcholine, acetylcholinesterase (AChE) has been shown through in vitro demonstrations to be able to promote various non-cholinergic ...
Regulators of dormancy/viability of Mycobacterium tuberculosis inside the human macrophages

Botha, Maria Magdalena (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: The investigation was aimed to improve the understanding of the binding interactions between DevS and DevR that are implicated in the regulation of the dormancy response in Mycobacterium tuberculosis. ...
Investigating ligands of cardiac Myosin-Binding Protein C (cMyBPC) as potential regulators of contractility and modifiers of hypertrophy.

Swanepoel, C. C. A. (Stellenbosch : Stellenbosch University, 2011-12)

ENGLISH ABSTRACT: The regulation of cardiac contractility is dependent on cooperative interaction between the thick and thin filaments, as well as their accessory proteins, within the cardiac sarcomere. Alteration in cardiac ...
Nitrogen metabolism and the regulation thereof in Mycobacterium smegmatis

Kirsten, Catriona Jane (Stellenbosch : University of Stellenbosch, 2011-12)

ENGLISH ABSTRACT: The nitrogen metabolic pathway is essential for growth and survival of all living organisms including prokaryotes. Certain components of the pathway, such as the enzyme glutamine synthetase (GS), have ...
A candidate and novel gene search to identify the PFHBII-causative gene

Fernandez, Pedro (Pedro Wallace) (Stellenbosch : University of Stellenbosch, 2004-12)

ENGLISH ABSTRACT: Heart failure due to cardiomyopathy or cardiac conduction disease is a major cause of mortality and morbidity in both developed and developing countries. Although defined as separate clinical entities, ...
An investigation of myosin binding protein C mutations in South Africa and a search for ligands binding to myosin binding protein C

De Lange, W. J. (Willem Jacobus) (Stellenbosch : University of Stellenbosch, 2004-12)

ENGLISH ABSTRACT: Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited primary cardiac disease. The primary features of HCM are left ventricular hypertrophy, myocardial disarray, fibrosis and an increased ...

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