• Molecular and functional characterisation of Long QT Syndrome causing genes 

  Hedley, Paula Louise (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Ventricular arrhythmias are the most important cause of sudden cardiac death (SCD) among adults living in industrialised nations. Genetic factors have substantial effects in determining population-based ...
• The evolution of the Mycobacterium tuberculosis proteome in response to the development of drug resistance 

  Fortuin, Suereta (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: This study is the first of its kind to highlight the importance of using the latest state of the art technology available in the field of proteomics as a complementary tool to characterize the proteome ...
• Identification of mechanisms regulating the intra cellular concentration of rifampicin in Mycobacterium Tuberculosis 

  De Vos, Margaretha (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Rifampicin resistance in clinical isolates of Mycobacterium tuberculosis develops through selection of bacterial variants harbouring mutations in the rpoB gene. These mutations infer a fitness-cost in the ...
• Understanding the evolution and function of the mycobacterial Type VII ESX secretion systems (T7SSs) and their substrates 

  Newton-Foot, Mae (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, contains five copies of the ESAT-6 gene cluster, each encoding a dedicated ESX protein secretion system which has been defined as ...
• Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis 

  Barnard, Marinus (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship ...
• Renin-angiotensin-aldosterone system genes and the complex hypertrophic phenotype of hypertrophic cardiomyopathy 

  Carstens, Nadia (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is a strong independent predictor of cardiovascular morbidity and mortality, while its regression is associated with an improved clinical prognosis. It is, therefore, ...
• The development of a novel fluorescentmarker phage technology system for the early diagnosis of tuberculosis disease 

  Van der Merwe, Ruben Gerhard (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ...
• Gene expression and cytokine pattern of pulmonary tuberculosis patients and their contacts in Ethiopia 

  Bekele, Adane Mihret (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: The immune response against M. tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics ...
• Pharmacogenetics of Arylamine N-acetyltransferase genes in South African populations 

  Werely, Cedric J. (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Tuberculosis (TB) has been declared a global health emergency by the World Health Organisation, and consequently there is an urgency to develop improved methods of diagnosis and treatment. Despite the ...
• Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens 

  Bruiners, Natalie (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the ESX-1 secretion system. ...
• Elucidation of the mode of action of a furanone based antituberculosis compound 

  Ngwane, Andile Happyboy (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: The prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has been increasing to alarming levels globally. This has been exacerbated by tuberculosis ...
• Role of cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) and p38 mitogen activated protein kinase (p38 MAPK) in preconditioning of the ischaemic myocardium 

  Marais, Erna (Stellenbosch : Stellenbosch University, 2002-12)

  ENGLISH ABSTRACT: Ischaemic preconditioning (PC) is the phenomenon whereby a short episode of coronary occlusion followed by reperfusion protects the myocardium against a subsequent period of prolonged (also called index ...
• Mycobacterium tuberculosis : genetic and phenotypic comparison 

  Sampson, Samantha Leigh (Stellenbosch : Stellenbosch University, 2002-03)

  ENGLISH ABSTRACT: This study exploits the Mycobacterium tuberculosis H37Rv genome sequence data in the context of M. tuberculosis clinical isolates, to elucidate genetic variation, and examine the phenotypic and molecular ...
• A candidate and novel gene search to identify the PFHBII-causative gene 

  Fernandez, Pedro (Stellenbosch : Stellenbosch University, 2004-12)

  ENGLISH ABSTRACT: Heart failure due to cardiomyopathy or cardiac conduction disease is a major cause of mortality and morbidity in both developed and developing countries. Although defined as separate clinical entities, ...
• Functional and genetic study of M. tuberculosis glutamine synthetase (GS) and other factors possibly involved in GS metabolism 

  Hayward, Don (Stellenbosch : Stellenbosch University, 2007-12)

  ENGLISH ABSTRACT: Sequence analysis showed that the essential glnA1 gene of Mycobacterium tuberculosis might be closely related to an actinomycetes progenitor sequence and that this sequence may have undergone duplication ...
• Molecular genetic strategies to identify Obsessive-compulsive disorder (OCD) and schizophrenia candidate genes in a South African sub-population group 

  Kinnear, C. J. (Craig John) (Stellenbosch : Stellenbosch University, 2007-12)

  ENGLISH ABSTRACT: Obsessive-compulsive disorder is a severe, debilitating psychiatric disorder for which the underlying molecular aetiology still remains unclear. Evidence from family studies have suggested that OCD may ...
• Immune parameters as biomarkers of Mycobacterium tuberculosis sterilization during anti-tuberculosis treatment 

  Djoba Siawaya, Joel Fleury (Stellenbosch : Stellenbosch University, 2008-03)

  ENGLISH ABSTRACT: Setting Study conducted in Tygerberg, Cape Town in South Africa. Hypothesis Host biomarkers associated with the antimycobacterial immune response during active infection with M. tuberculosis and during ...
• Characterization of the interaction between acetylcholinesterase and laminin : a template for discovering redundancy 

  Swart, Chrisna (Stellenbosch : Stellenbosch University, 2012-03)

  ENGLISH ABSTRACT: Apart from its primary function in the synaptic hydrolysis of acetylcholine, acetylcholinesterase (AChE) has been shown through in vitro demonstrations to be able to promote various non-cholinergic ...
• Regulators of dormancy/viability of Mycobacterium tuberculosis inside the human macrophages 

  Botha, Maria Magdalena (Stellenbosch : Stellenbosch University, 2012-03)

  ENGLISH ABSTRACT: The investigation was aimed to improve the understanding of the binding interactions between DevS and DevR that are implicated in the regulation of the dormancy response in Mycobacterium tuberculosis. ...
• Investigating ligands of cardiac Myosin-Binding Protein C (cMyBPC) as potential regulators of contractility and modifiers of hypertrophy. 

  Swanepoel, C. C. A. (Stellenbosch : Stellenbosch University, 2011-12)

  ENGLISH ABSTRACT: The regulation of cardiac contractility is dependent on cooperative interaction between the thick and thin filaments, as well as their accessory proteins, within the cardiac sarcomere. Alteration in cardiac ...

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