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The effects of chronic melatonin treatment on myocardial function and ischaemia and reperfusion injury in a rat model of diet-induced obesity

Nduhirabandi, Frederic (Stellenbosch : Stellenbosch University, 2010-03)

ENGLISH ABSTRACT: Obesity is a major risk factor for ischaemic heart disease. Obesity-induced metabolic abnormalities have been associated with increased oxidative stress which may play an important role in the increased ...
A pathologic role for angiotensin II and endothelin-1 in cardiac remodelling and ischaemia and reperfusion injury in a rat model of the metabolic syndrome

Smith, Wayne (Stellenbosch : University of Stellenbosch, 2006-03)

Introduction: Obesity, which is implicated in the development of the metabolic syndrome (MS) is reaching epidemic proportions worldwide. MS significantly increases the risk of developing cardiovascular disease, which ...