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The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity

Perel, Shireen J. C. (Stellenbosch : University of Stellenbosch, 2009-03)

Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1, phosphatidylinositol-3-kinase and protein ...
A pathologic role for angiotensin II and endothelin-1 in cardiac remodelling and ischaemia and reperfusion injury in a rat model of the metabolic syndrome

Smith, Wayne (Stellenbosch : University of Stellenbosch, 2006-03)

Introduction: Obesity, which is implicated in the development of the metabolic syndrome (MS) is reaching epidemic proportions worldwide. MS significantly increases the risk of developing cardiovascular disease, which ...