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Role of glycogen synthase kinase 3 (GSK-3) and its substrate proteins in the development of cardiomyopathy associated with obesity and insulin resistance

Flepisi, Thabile Brian (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: INTRODUCTION: Glycogen synthase kinase-3 (GSK-3) is a serine-threonine protein kinase that was first discovered as a regulator of glycogen synthase thus playing a role in glycogen synthesis (Embi et al. ...
The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance

Lubelwana Hafver, Tandekile (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany these disease ...