Search

Now showing items 1-10 of 13

HIV and childhood tuberculosis: The way forward

Cotton M.F.; Schaaf H.S.; Hesseling A.C.; Madhi S.A. (2004)

Tuberculosis has been a major cause of morbidity and mortality in under-resourced communities. By causing progressive immunodeficiency, the human immunodeficiency virus (HIV) increases susceptibility to tuberculosis in an ...

Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...

Tuberculosis in oncology patients

Stefan D.C.; Kruis A.L.; Schaaf H.S.; Wessels G. (2008)

Background: There is a dearth of studies addressing the incidence and clinical presentation of tuberculosis (TB) in children with cancer. Aim: To evaluate the incidence of TB in paediatric oncology patients at Tygerberg ...

Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity

Marais B.J.; Hesseling A.C.; Schaaf H.S.; Gie R.P.; Van Helden P.D.; Warren R.M. (2009)

Among the different strains of Mycobacterium tuberculosis, Beijing has been identified as an emerging genotype. Enhanced transmissibility provides a potential mechanism for genotype selection. This study evaluated whether ...

Resistant Mycobacterium bovis Bacillus Calmette-Guérin Disease: Implications for Management of Bacillus Calmette-Guérin Disease in Human Immunodeficiency Virus-Infected Children

Hesseling A.C.; Schaaf H.S.; Victor T.; Beyers N.; Marais B.J.; Cotton M.F.; Wiid I.; Gie R.P.; Van Helden P.; Warren R.M. (2004)

Guidelines for the diagnosis and management of Bacillus Calmette-Guérin (BCG) disease in children are lacking, and there are limited data on drug resistance of Mycobacterium bovis BCG. A 6-month-old HIV-infected infant ...

Twice weekly vs. daily chemotherapy for childhood tuberculosis

Te Water Naude J.M.; Donald P.R.; Hussey G.D.; Kibel M.A.; Louw A.; Perkins D.R.; Schaaf H.S. (2000)

Background. Treating childhood tuberculosis places a large burden on health services, and ways of lessening this were sought. Methods. A randomized controlled trial was conducted to determine the effectiveness of fully ...

The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis

Goussard P.; Gie R.P.; Kling S.; Schaaf H.S.; Kritzinger F.; Andronikou S.; Beyers N.; Rossouw G.J. (2008)

Introduction: The outcome of young infants (<6 months) being ventilated for respiratory failure caused by Mycobacterium tuberculosis (MTB) has not been recorded. Patients and Methods: A descriptive study of children <6 ...

Recurrent culture-confirmed tuberculosis in human immunodeficiency virus-infected children

Schaaf H.S.; Krook S.; Hollemans D.W.; Warren R.M.; Donald P.R.; Hesseling A.C. (2005)

Introduction: Recurrent tuberculosis (TB) is more common among human immunodeficiency virus (HIV)-infected than HIV-uninfected adults. There are limited data regarding recurrence of TB in children. Objective: To determine ...

Transmission of multidrug-resistant tuberculosis

Schaaf H.S.; Van Rie A.; Gie R.P.; Beyers N.; Victor T.C.; Van Helden P.D.; Donald P.R. (2000)

Aim. To compare the Mycobacterium tuberculosis isolates of adult index cases with multidrug-resistant (MDR) tuberculosis to the isolates obtained from their child contacts. Patients and methods. A 4-year prospective study ...

Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis

Maree F.; Hesseling A.C.; Schaaf H.S.; Marais B.J.; Beyers N.; Van Helden P.; Warren R.M.; Schoeman J.F. (2007)

OBJECTIVES: Animal studies point to increased virulence of certain mycobacterial strains, notably those of the Beijing genotype. There are limited data on mycobacterial genotypic diversity in children with tuberculous ...