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High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial

Hesseling A.C.; Kim S.; Madhi S.; Nachman S.; Schaaf H.S.; Violari A.; Victor T.C.; McSherry G.; Mitchell C.; Cotton M.F. (2012)

An emergence of drug-resistant tuberculosis (DR-TB) in settings affected by human immunodeficiency virus (HIV) and tuberculosis (TB) has been observed. We investigated the prevalence of DR-TB in P1041, a multicentred, ...

Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer

Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)

SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...

Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...

Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa

Schaaf H.S.; Marais B.J.; Hesseling A.C.; Gie R.P.; Beyers N.; Donald P.R. (2006)

Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...

Opportunities for chemoprophylaxis in children with culture-confirmed tuberculosis

Du Preez K.; Hesseling A.C.; Mandalakas A.M.; Marais B.J.; Schaaf H.S. (2011)

Papulonecrotic tuberculid in children: A report of eight patients

Jordaan H.F.; Schneider J.W.; Schaaf H.S.; Victor T.S.; Geiger D.H.; Van Helden P.D.; Rossouw D.J. (1996)

Papulonecrotic tuberculid (PNT), a form of cutaneous tuberculosis (TB), is uncommon in children. We identified eight children (six girls and two boys) with PNT. Their ages ranged from 19 to 139 months (median: 47.5 months, ...

Tuberculosis in oncology patients

Stefan D.C.; Kruis A.L.; Schaaf H.S.; Wessels G. (2008)

Background: There is a dearth of studies addressing the incidence and clinical presentation of tuberculosis (TB) in children with cancer. Aim: To evaluate the incidence of TB in paediatric oncology patients at Tygerberg ...

Pharmacokinetics of isoniazid, rifampin,and pyrazinamide in children younger than two years of age with tuberculosis: Evidence for implementation of revised World Health Organization recommendations

Thee S.; Seddon J.A.; Donald P.R.; Seifart H.I.; Werely C.J.; Hesseling A.C.; Rosenkranz B.; Roll S.; Magdorf K.; Schaaf H.S. (2011)

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Culture-positive tuberculosis in human immunodeficiency virus type 1- infected children

Schaaf H.S.; Geldenduys A.; Gie R.P.; Cotton M.F. (1998)

Background. Adults infected by HIV have increased susceptibility to Mycobacterium tuberculosis and progress more rapidly to disease. HIV and tuberculosis (TB) coinfection in children has been reported but often lacks ...