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The burden of childhood tuberculosis: A public health perspective
The burden of childhood tuberculosis (TB) reflects recent transmission within a community and the level of TB control achieved within the adult (maintenance host) population. Children contribute little to the maintenance ...
Isoniazid pharmacokinetics in children treated for respiratory tuberculosis
Aims: To define the pharmacokinetics of isoniazid (INH) in children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype. Methods: The first order elimination rate constant (k) and area under the ...
Tuberculous meningitis and miliary tuberculosis: The Rich focus revisited
Tuberculous meningitis (TBM) develops most often when a caseating meningeal or sub-cortical focus, the Rich focus, discharges its contents into the subarachnoid space. It is recognized that TBM is frequently accompanied ...
Recurrent culture-confirmed tuberculosis in human immunodeficiency virus-infected children
Introduction: Recurrent tuberculosis (TB) is more common among human immunodeficiency virus (HIV)-infected than HIV-uninfected adults. There are limited data regarding recurrence of TB in children. Objective: To determine ...