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    High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial 

    Hesseling A.C.; Kim S.; Madhi S.; Nachman S.; Schaaf H.S.; Violari A.; Victor T.C.; McSherry G.; Mitchell C.; Cotton M.F. (2012)
    An emergence of drug-resistant tuberculosis (DR-TB) in settings affected by human immunodeficiency virus (HIV) and tuberculosis (TB) has been observed. We investigated the prevalence of DR-TB in P1041, a multicentred, ...
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    Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer 

    Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)
    SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...
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    Ethionamide cross-and co-resistance in children with isoniazid-resistant tuberculosis 

    Schaaf H.S.; Victor T.C.; Venter A.; Brittle W.; Jordaan A.M.; Hesseling A.C.; Marais B.J.; Van Helden P.D.; Donald P.R. (2009)
    BACKGROUND: Ethionamide (ETH) is a structural analogue of isoniazid (INH). Both are pro-drugs requiring activation by separate and common enzyme pathways, which could lead to co-and/or cross-resistance. OBJECTIVE: To ...
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    Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting 

    Cotton M.F.; Schaaf H.S.; Lottering G.; Weber H.L.; Coetzee J.; Nachman S. (2008)
    Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, ...
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    A prospective evaluation of children under the age of 5 years living in the same household as adults with recently diagnosed pulmonary tuberculosis 

    Beyers N.; Gie R.P.; Schaaf H.S.; Van Zyl S.; Talent J.M.; Nel E.D.; Donald P.R. (1997)
    SETTING: A South African suburb with a high tuberculosis incidence (>800/100 000). OBJECTIVE: To determine the prevalence of tuberculosis infection and disease in children less than 5 years of age who were in close household ...
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    Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid 

    Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)
    Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...
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    High incidence of tuberculosis among HIV-infected infants: Evidence from a South African population-based study highlights the need for improved tuberculosis control strategies 

    Hesseling A.C.; Cotton M.F.; Jennings T.; Whitelaw A.; Johnson L.F.; Eley B.; Roux P.; Godfrey-Faussett P.; Schaaf H.S. (2009)
    Background. There are limited population-based estimates of tuberculosis incidence among human immunodeficiency virus (HIV)-infected and HIV-uninfected infants aged ≤12 months. We aimed to estimate the population-based ...
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    Isoniazid pharmacokinetics in children treated for respiratory tuberculosis 

    Schaaf H.S.; Parkin D.P.; Seifart H.I.; Werely C.J.; Hesseling P.B.; Van Helden P.D.; Maritz J.S.; Donald P.R. (2005)
    Aims: To define the pharmacokinetics of isoniazid (INH) in children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype. Methods: The first order elimination rate constant (k) and area under the ...
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    Opportunities for chemoprophylaxis in children with culture-confirmed tuberculosis 

    Du Preez K.; Hesseling A.C.; Mandalakas A.M.; Marais B.J.; Schaaf H.S. (2011)
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    Tuberculosis in oncology patients 

    Stefan D.C.; Kruis A.L.; Schaaf H.S.; Wessels G. (2008)
    Background: There is a dearth of studies addressing the incidence and clinical presentation of tuberculosis (TB) in children with cancer. Aim: To evaluate the incidence of TB in paediatric oncology patients at Tygerberg ...
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    Schaaf H.S. (33)
    Hesseling A.C. (15)Cotton M.F. (10)Donald P.R. (10)Marais B.J. (9)Beyers N. (7)Gie R.P. (6)Van Helden P.D. (5)Warren R.M. (5)Victor T.C. (4)... View MoreSubjecthuman (33)
    infant (33)
    article (30)priority journal (24)Humans (22)isoniazid (22)Infant (21)child (20)female (20)male (20)... View MoreDate Issued2010 - 2012 (8)2000 - 2009 (20)1991 - 1999 (5)Has File(s)No (33)
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