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    High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial 

    Hesseling A.C.; Kim S.; Madhi S.; Nachman S.; Schaaf H.S.; Violari A.; Victor T.C.; McSherry G.; Mitchell C.; Cotton M.F. (2012)
    An emergence of drug-resistant tuberculosis (DR-TB) in settings affected by human immunodeficiency virus (HIV) and tuberculosis (TB) has been observed. We investigated the prevalence of DR-TB in P1041, a multicentred, ...
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    Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer 

    Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)
    SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...
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    Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid 

    Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)
    Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...
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    Opportunities for chemoprophylaxis in children with culture-confirmed tuberculosis 

    Du Preez K.; Hesseling A.C.; Mandalakas A.M.; Marais B.J.; Schaaf H.S. (2011)
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    Pharmacokinetics of isoniazid, rifampin,and pyrazinamide in children younger than two years of age with tuberculosis: Evidence for implementation of revised World Health Organization recommendations 

    Thee S.; Seddon J.A.; Donald P.R.; Seifart H.I.; Werely C.J.; Hesseling A.C.; Rosenkranz B.; Roll S.; Magdorf K.; Schaaf H.S. (2011)
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    Management of tuberculosis in children and new treatment options 

    Marais B.J.; Schaaf H.S.; Donald P.R. (2011)
    Childhood tuberculosis (TB) continues to be a neglected disease in areas where limited resources restrict the focus of national TB control programmes to only the most infectious sputum smear-positive cases. However, ...
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    Tuberculosis at extremes of age 

    Schaaf H.S.; Collins A.; Bekker A.; Davies P.D.O. (2010)
    Although tuberculosis (TB) has its highest burden among young adults, especially since the advent of HIV infection, two other groups with low immunity, the very young (<1 year) with immature immunity and the elderly (>65 ...
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    Management of drug-resistant tuberculosis 

    Chiang C.-Y.; Schaaf H.S. (2010)
    Drug-resistant tuberculosis (DR-TB) in adults is either acquired due to poor treatment management or transmitted from infectious DR-TB cases, while children mainly have transmitted disease. Diagnosis of DR-TB relies on ...
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    Drug-resistant tuberculosis: Pediatric guidelines 

    Al-Dabbagh M.; Lapphra K.; McGloin R.; Inrig K.; Schaaf H.S.; Marais B.J.; Sauve L.; Kitai I.; Kollmann T.R. (2011)
    Drug-resistant Mycobacterium tuberculosis (TB) infection represents a serious and growing problem. For patients infected or suspected of being infected with multidrug or extensively drug-resistant TB, several medications ...
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    Abnormal thyroid function tests in children on ethionamide treatment 

    Thee S.; Zollner E.W.; Willemse M.; Hesseling A.C.; Magdorf K.; Schaaf H.S. (2011)
    Ethionamide (ETH) treatment may cause hypothyroidism. Clinical data, serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were retrospectively assessed in 137 children receiving anti-tuberculosis treatment ...
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    Schaaf H.S. (29)
    Hesseling A.C. (14)Marais B.J. (9)Seddon J.A. (7)Donald P.R. (6)Cotton M.F. (5)Victor T.C. (5)Gie R.P. (4)Du Preez K. (3)Magdorf K. (3)... View MoreSubjecthuman (14)priority journal (12)isoniazid (11)child (10)rifampicin (10)article (9)Mycobacterium tuberculosis (9)controlled study (8)Human immunodeficiency virus infection (8)infant (8)... View MoreDate Issued2011 (13)2012 (9)2010 (7)Has File(s)No (29)
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