Now showing items 1-10 of 103
Pyrazinamide plasma concentrations in young children with tuberculosis
Pyrazinamide plasma concentrations were determined in 34 children (median age, 3.32 years) 1 month after commencing antituberculosis treatment. The median (interquartile range) peak concentration was 30.7 (25.5, 35.0) mg/L ...
Children and tuberculosis: Protecting the next generation?
[No abstract available]
Hepatic toxicity during chemotherapy for severe tuberculous meningitis
The possible development of hepatotoxic effects as a result of high dosages of isoniazid, rifampin, pyrazinamide, and ethionamide was assessed in 56 young children (median age, 22 months) treated for severe tuberculous ...
Serial lumbar CSF pressure measurements and cranial computed tomographic findings in childhood tuberculous meningitis
Intracranial pressure (ICP) was monitored in 218 consecutive children with hydrocephalus secondary to tuberculous meningitis (TBM). All children underwent cranial computerized tomographic (CT) scanning and continuous lumbar ...
Tuberculosis presenting in the neonatal periodd
Tuberculosis presenting during the neonatal period is uncommon, but does occur and may prove fatal if not diagnosed in a timely manner. We describe four such cases and draw attention to urogenital tuberculosis in the mother ...
Drug treatment of tuberculosis meningitis in children. A practical guide
Treatment must be continued for a minimum of 6 months, but should be extended to 9 or 12 months if rifampicin cannot be used throughout and if pyrazinamide cannot be used for the first 2 months of treatment. Hydrocephalus ...
The assessment of new anti-tuberculosis drugs for a paediatric indication
For the first time in three decades there is a promising pipeline of more than 20 new anti-tuberculosis agents at various stages of development, and several are already entering early clinical trials. Childhood tuberculosis ...
Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid
Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...
Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa
Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...
Nosocomial infections in HIV-infected and HIV-uninfected children hospitalised for tuberculosis
Background: The interaction between tuberculosis and HIV-infected infection is well known and is responsible for the increase in the incidence of tuberculosis (TB) in sub-Saharan Africa over the last decade. This places a ...