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Ethionamide cross-and co-resistance in children with isoniazid-resistant tuberculosis

Schaaf H.S.; Victor T.C.; Venter A.; Brittle W.; Jordaan A.M.; Hesseling A.C.; Marais B.J.; Van Helden P.D.; Donald P.R. (2009)

BACKGROUND: Ethionamide (ETH) is a structural analogue of isoniazid (INH). Both are pro-drugs requiring activation by separate and common enzyme pathways, which could lead to co-and/or cross-resistance. OBJECTIVE: To ...

Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity

Marais B.J.; Hesseling A.C.; Schaaf H.S.; Gie R.P.; Van Helden P.D.; Warren R.M. (2009)

Among the different strains of Mycobacterium tuberculosis, Beijing has been identified as an emerging genotype. Enhanced transmissibility provides a potential mechanism for genotype selection. This study evaluated whether ...