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Activation of p38 MAPK induced by a multi-cycle ischaemic preconditioning protocol is associated with attenuated p38 MAPK activity during sustained ischaemia and reperfusion

Marais E. Genade S. Huisamen B. Strijdom J.G. Moolman J.A. Lochner A. (2001)

The role of p38 mitogen-activated protein kinase (MAPK) in ischaemic preconditioning remains controversial. Since most previous studies focussed on events only during sustained ischaemia, the aim of this study was to ...
A mechanism for zinc toxicity in neuroblastoma cells

Daniels W.M.U. Hendricks J. Salie R. Van Rensburg S.J. (2004)

Zinc is an important component of proteins essential for normal functioning of the brain. However, it has been shown in vitro that this metal, at elevated levels, can be toxic to cells leading to their death. We investigated ...
p38 MAPK activation triggers pharmacologically-induced β-adrenergic preconditioning, but not ischaemic preconditioning

Marais E. Genade S. Strijdom H. Moolman J.A. Lochner A. (2001)

p38 Mitogen-activated protein kinase (p38 MAPK) is activated by short episodes of ischaemia-reperfusion as well as by sustained ischemia followed by reperfusion. Whether activation of this kinase is beneficial or deleterious ...
The role of the MAP-kinase superfamily in β-amyloid toxicity

Daniels W.M.U. Hendricks J. Salie R. Taljaard J.J.F. (2001)

The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well ...