Work in Progress


Sub-communities within this community

Collections in this community

Recent Submissions

  • Directly interrogating single quantum dot labelled UvrA2 molecules on DNA tightropes using an optically trapped nanoprobe 

    Simons, Michelle; Pollard, Mark R.; Hughes, Craig D.; Ward, Andrew D.; Van Houten, Bennett; Towrie, Mike; Botchway, Stan W.; Parker, Anthony W.; Kad, Neil M. (Springer Nature, 2016)
    In this study we describe a new methodology to physically probe individual complexes formed between proteins and DNA. By combining nanoscale, high speed physical force measurement with sensitive fluorescence imaging we ...

  • Diversity of burial rates in convergent settings decreased as Earth aged 

    Nicoli, Gautier; Moyen, Jean-Francois; Stevens, Gary (Springer Nature, 2016)
    The evolution and the growth of the continental crust is inextricably linked to the evolution of Earth’s geodynamic processes. The detrital zircon record within the continental crust, as well as the isotopic composition ...

  • A general method for parameter estimation in light-response models 

    Chen, Lei; Li, Zhong-Bin; Hui, Cang; Cheng, Xiaofei; Li, Bai-Lian; Shi, Pei-Jian (Springer Nature, 2016)
    Selecting appropriate initial values is critical for parameter estimation in nonlinear photosynthetic light response models. Failed convergence often occurs due to wrongly selected initial values when using currently ...

  • Engineering of a novel cellulose-adherent cellulolytic Saccharomyces cerevisiae for cellulosic biofuel production 

    Liu, Zhuo; Ho, Shih-Hsin; Sasaki, Kengo; Den Haan, Riaan; Inokuma, Kentaro; Ogino, Chiaki; Van Zyl, Willem H.; Hasunuma, Tomohisa; Kondo, Akihiko (Springer Nature, 2016)
    Cellulosic biofuel is the subject of increasing attention. The main obstacle toward its economic feasibility is the recalcitrance of lignocellulose requiring large amount of enzyme to break. Several engineered yeast strains ...

  • Age differences between sexual partners, behavioural and demographic correlates, and HIV infection on Likoma Island, Malawi 

    Beauclair, Roxanne; Helleringe, Stephane; Hens, Niel; Delva, Wim (Springer Nature, 2016)
    Patterns of age differences between sexual partners – age-mixing – may partially explain the magnitude of HIV epidemics in Sub-Saharan Africa. However, evidence of age-disparity as a risk factor for HIV remains mixed. We ...

  • Stoichiometry patterns in the androdioecious Acer tegmentosum 

    Zhang, Xinna; Yao, Jie; Fan, Chunyu; Tan, Lingzhao; Zhang, Chunyu; Wang, Juan; Zhao, Xiuhai; Von Gadow, Klaus (Springer Nature, 2016)
    This study evaluates stoichiometry patterns in the androdioecious Acer tegmentosum, a species characterized by a rare reproductive system where males and hermaphrodites coexist. Altogether 31 hermaphrodites and 29 male ...

  • Deneys Reitz and the First World War : an Introduction to the Department of Defence Archival Holdings 

    Kleynhans, Evert (Stellenbosch University, Faculty of Military Science (Military Academy), 2016)
    The historical sources detailing South Africa’s participation in the First World War are vast, and range from official publications to regimental histories, private diaries and first-hand accounts. The Department of Defence ...

  • Tracking the cellulolytic activity of Clostridium thermocellum biofilms 

    Dumitrache, Alexandru; Wolfaardt, Gideon M.; Allen, David Grand; Liss, Steven N.; Lynd, Lee R. (BioMed Central, 2013-11-29)
    Background Microbial cellulose conversion by Clostridium thermocellum 27405 occurs predominantly through the activity of substrate-adherent bacteria organized in thin, primarily single cell-layered biofilms. The importance ...

  • Maternal deaths from bleeding associated with caesarean delivery : a national emergency 

    Fawcus, S.; Pattinson, R. C.; Moodley, J.; Moran, N. F.; Schoon, M. G.; Mhlanga, R. E.; Baloyi, S.; Bekker, E.; Gebhardt, G. S. (Health & Medical Publishing Group, 2016)
    Maternal deaths associated with caesarean deliveries (CDs) have been increasing in South Africa over the past decade. The objective of this report is to bring national attention to this increasing epidemic of maternal ...

  • First report of Wohlfahrtiimonas chitiniclastica bacteraemia in South Africa 

    Hoffman, R.; Fortuin, F.; Newton-Foot, M.; Singh, S. (Health & Medical Publishing Group, 2016)
    No abstract available

  • Risk of cardiovascular disease among teachers in Cape Town : findings of the South African PaCT pilot study 

    Laurence, E. C.; Volmink, J.; Esterhuizen, T. M.; Dalal, S.; Holmes, M. D. (Health & Medical Publishing Group, 2016)
    Background. The accelerating epidemic of cardiovascular disease (CVD) and other non-communicable diseases (NCDs) highlights the need to establish long-term cohort studies in Africa. Objective. The Partnership for Cohort ...

  • High prevalence of cardiovascular risk factors in Durban South African Indians : the Phoenix Lifestyle Project 

    Prakaschandra, Dorcas Rosaley; Esterhuizen, Tonya M.; Motala, Ayesha A.; Gathiram, Prem; Naidoo, Datshana Prakesh (Health & Medical Publishing Group, 2016)
    Background. Previous studies show a high prevalence of cardiovascular (CV) risk factors in South African (SA) Asian Indians, with the emergence of premature coronary artery disease in young Indian subjects. Objective. ...

  • Evaluating point-of-care testing for glycosylated haemoglobin in public sector primary care facilities in the Western Cape, South Africa 

    Mash, R.; Ugoagwu, A.; Vos, C.; Rensburg, M.; Erasmus, R. (Health & Medical Publishing Group, 2016)
    Background. Diabetes mellitus contributes significantly to the burden of disease in South Africa (SA). Monitoring of glycaemic control with glycosylated haemoglobin (HbA1c) is recommended, even though current laboratory-based ...

  • South African Guidelines Excellence (SAGE) : What’s in a name? 

    Kredo, Tamara; Machingaidze, Shingai; Louw, Quinette; Young, Taryn; Grimmer, Karen (Health & Medical Publishing Group, 2016)
    Project SAGE (South African Guidelines Excellence) is a 3-year research project, funded by the South African Medical Research Council, through the South African University Flagship Project scheme ( ...

  • An effective approach to chronic kidney disease in South Africa 

    Moosa, Mohammed Rafique; Meyers, Anthony M.; Gottlich, Errol; Naicker, Sarala (Health & Medical Publishing Group, 2016)
    Very few patients with end-stage kidney disease in South Africa receive renal replacement treatment (RRT), despite the rapidly growing demand, because of resource constraints. Nephrologists who agonise daily about who to ...

  • South African Guidelines Excellence (SAGE) : efficient, effective and unbiased clinical practice guideline teams 

    Grimmer, Karen; Dizon, Janine Margarita; Louw, Quinette; Kredo, Tamara; Young, Taryn; Machingaidze, Shingai (Health & Medical Publishing Group, 2016)
    A range of different evidence-based methods for clinical practice guideline activities have been established, and there is common agreement in these that poorly conceived CPG team composition and management can jeopardise ...

  • An approach to the patient with a suspected tachycardia in the emergency department 

    Chin, Ashley; Vezi, Brian; Namane, Mosedi; Weich, Hellmuth; Scott-Millar, Rob (Health & Medical Publishing Group, 2016)
    Patients present to the emergency department with either an ongoing tachycardia or a history suspicious of a tachycardia. Either way, the tachycardia needs to be documented, preferably on a 12-lead electrocardiogram (ECG) ...

  • An approach to the patient with suspected pericardial disease 

    Kyriakakis, Charles G.; Mayosi, Bongani M.; De Vries, Elma; Isaacs, Abdul; Doubell, Anton F. (Health & Medical Publishing Group, 2016)
    Diseases of the pericardium commonly manifest in one of three ways: acute pericarditis, pericardial effusion and constrictive pericarditis. In the developed world, the most common cause of acute pericarditis is viral or ...

  • The impact of HIV infection on the presentation of lung cancer in South Africa 

    Koegelenberg, C. F. N.; Van Der Made, T.; Taljaard, J. J.; Irusen, E. M. (Health & Medical Publishing Group, 2016)
    Background. Despite the very high background prevalence of HIV and smoking-related diseases in sub-Saharan Africa, very little is known about the presentation of lung cancer in HIV-infected individuals. Methods. We ...

  • Clinical findings and genetic screening for copy number variation mutations in a cohort of South African patients with Parkinson’s disease 

    Mahne, Anna Cecelia; Carr, Jonathan A.; Bardien, Soraya; Schutte, Clara Maria (Health & Medical Publishing Group, 2016)
    Background. Parkinson’s disease (PD), with a prevalence of up to 4% in Western countries, appears to be less common in Africa, possibly in part because of genetic factors. African studies investigating the genetic causation ...

  • Collaborative Shared care to Improve Psychosis Outcome (COSIMPO) : study protocol for a randomized controlled trial 

    Gureje, Oye; Makanjuola, Victor; Kola, Lola; Yusuf, Bidemi; Price, Leshawndra; Esan, Oluyomi; Oladeji, Bibilola D.; Appiah-Poku, John; Haris, Benjamin; Othieno, Caleb; Seedat, Soraya (BioMed Central, 2017-10)
    Background: Psychotic disorders are a group of severe mental disorders that cause considerable disability to sufferers and a high level of burden to families. In many low- and middle-income countries (LMIC), traditional ...

  • Human rights and mental health in post-apartheid South Africa : lessons from health care professionals working with suicidal inmates in the prison system 

    Bantjes, Jason; Swartz, Leslie; Niewoudt, Pieter (BioMed Central, 2017-10-12)
    Background: During the era of apartheid in South Africa, a number of mental health professionals were vocal about the need for socio-economic and political reform. They described the deleterious psychological and social ...

  • Angio-oedema associated with colistin 

    Abulfathi, A. A.; Greyling, T.; Makiwane, M.; Esser, M.; Decloedt, E. (Health & Medical Publishing Group, 2016)
    A 50-year-old woman known to have type 1 diabetes mellitus presented with a rare case of angio-oedema associated with colistin use. The angio-oedema was temporally associated with the use and discontinuation of colistin ...

  • Private practice-driven research 

    Mashaphu, Sibongile; Chiliza, Bonginkosi (Health & Medical Publishing Group, 2016)
    No abstract available

  • Inappropriate antibiotic prescribing : a cross-sectional study in Swaziland 

    Chirima, Tapiwa; Esterhuizen, Tonya (Medpharm Publications, 2016)
    Background: A cross-sectional study was performed to determine the one-month prevalence of inappropriate antibiotic prescribing at the outpatient department of Hlatikulu Government Hospital, Swaziland. A survey was also ...

  • The heart team, TAVI and natural selection 

    Doubell, Anton (South African Heart Association, 2016)
    The announcement in 2002 that Alan Cribier had performed the first Transcatheter Aortic Valve Implantation (TAVI) ranked right up there with the announcement that the first heart transplant had been performed by Chris ...

  • Delivering cardiac care : the next frontier 

    Pecoraro, Alfonso J. K. (South African Heart Association, 2016)
    The 17th annual South African Heart congress, co-hosted with the annual meeting of the World Society of Cardiothoracic surgery, brings together both local and international pioneers in the field of cardiology and cardiothoracic ...

  • Tri-leafl et mitral valves – when lightning strikes thrice 

    Van Rensburg, Annari; Pecoraro, Alfonso; Kyriakakis, Charles; Herbst, Philip; Doubell, Anton (South African Heart Association, 2016)
    Mitral valves are well known to be bi-leaflet structures with attachments from both leaflets (anterior and posterior) to both papillary muscles (anterolateral and posteromedial). Congenital abnormalities of the mitral ...

  • When opportunity knocks 

    Van Rensburg, Annari; Kyriakakis, Charles; Pecoraro, Alfonso; Herbst, Philip (South African Heart Association, 2016)
    Constrictive pericarditis remains a common medical problem in developing countries where it frequently complicates tuberculous pericarditis. In addition, it is not infrequently seen in the developed world in the context ...

  • Cardiology training in South Africa – on the brink? 

    Doubell, Anton (South African Heart Association, 2016)
    More often than not, when we use the expression “on the brink”, we are referring to an impending bad situation. On the edge of a cliff without wings so to speak…, on the brink of disaster…, on the brink of ruin…, on the ...

View more