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Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer

Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)

SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...

Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures a prospective, controlled, randomized study of four hundred and fifty patients

Govender S.; Csimma C.; Genant H.K.; Valentin-Opran A.; Amit Y.; Arbel R.; Aro H.; Atar D.; Bishay M.; Borner M.G.; Chiron P.; Choong P.; Cinats J.; Courtenay B.; Feibel R.; Geulette B.; Govender S.; Gravel C.; Haas N.; Raschke M.; Hammacher E.; Van der Velde D.; Hardy P.; Holt M.; Josten C.; Ketterl R.L.; Lindeque B.; Lob G.; Mathevon H.; McCoy G.; Marsh D.; Miller R.; Munting E.; Oevre S.; Nordsletten L.; Patel A.; Pohl A.; Rennie W.; Reynders P.; Rommens P.M.; Rondia J.; Rossouw W.C.; Daneel P.J.; Ruff S.; Ruter A.; Santavirtal S.; Schidhauer T.A.; Gekle C.; Schnettler R.; Segal D.; Seiler H.; Snowdowne R.B.; Stapert J.; Taglang G.; Verdonik R.; Vogels L.; Weckbach A.; Wentzensen A.; Wisriewsk T. (2002)

Background: The treatment of open fractures of the tibial shaft is often complicated by delayed union and non-union. The objective of this study was to evaluate the safety and efficacy of the use of recombinant human bone ...

Phase II trial of ZD0473 as second-line therapy in mesothelioma

Giaccone G.; O'Brien M.E.R.; Byrne M.J.; Bard M.; Kaukel E.; Smit B. (2002)

A phase II, open-label, non-comparative, multicentre trial of the platinum analogue ZD0473 as second-line therapy for pleural mesothelioma has been completed. The objectives were to evaluate the activity and tolerability ...

Esomeprazole 40 mg administered intravenously has similar safety and efficacy profiles to the oral formulation in patients with erosive esophagitis

Schneider, H.; Van Rensburg, C.; Schmidt, S.; Aboo, N.; Makela, H.; Naucler, E.; Hallerback, B.; Svedberg, L-E. (2004)

Background/Aims: An intravenous formulation of esomeprazole has been developed for use in patients where oral administration is not appropriate. This study evaluated safety after 1 and 4 weeks, and efficacy after 4 weeks' ...

Comparable clinical efficacy and tolerability of 20 mg pantoprazole and 20 mg omeprazole in patients with grade I reflux oesophagitis

Bardhan K.D.; Van Rensburg C. (2001)

Background: Several clinical trials have shown that pantoprazole (40 mg) and omeprazole (40 or 20 mg) have similar efficacy and safety in the treatment of grade II-IV reflux oesophagitis (Savary-Miller classification). ...

Efficacy and safety of pantoprazole versus ranitidine in the treatment of patients with symptomatic gastroesophageal reflux disease

Van Zyl J.; Van Rensburg C.; Vieweg W.; Fischer R. (2004)

Background/Aim: Gastroesophageal reflux disease (GERD) is a prevalent disease associated with a high symptom burden and a reduced quality of life. This multicenter, randomized, double-blind study compared relief from key ...

Comparison of two active case-finding strategies for community-based diagnosis of symptomatic smear-positive tuberculosis and control of infectious tuberculosis in Harare, Zimbabwe (DETECTB): A cluster-randomised trial

Corbett E.L.; Bandason T.; Duong T.; Dauya E.; Makamure B.; Churchyard G.J.; Williams B.G.; Munyati S.S.; Butterworth A.E.; Mason P.R.; Mungofa S.; Hayes R.J. (2010)

Background Control of tuberculosis in settings with high HIV prevalence is a pressing public health priority. We tested two active case-finding strategies to target long periods of infectiousness before diagnosis, which ...

Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study

Stryjewski M.E.; Chu V.H.; O'Riordan W.D.; Warren B.L.; Dunbar L.M.; Young D.M.; Vallee M.; Fowler Jr. V.G.; Morganroth J.; Barriere S.L.; Kitt M.M.; Corey G.R. (2006)

Telavancin is a bactericidal lipoglycopeptide with a multifunctional mechanism of action. We conducted a randomized, double blind, active-control phase II trial. Patients S18 years of age with complicated skin and skin ...

Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin

Yeomans N.; Lanas A.; Labenz J.; Van Zanten S.V.; Van Rensburg C.; Racz I.; Tchernev K.; Karamanolis D.; Roda E.; Hawkey C.; Naucler E.; Svedberg L.-E. (2008)

OBJECTIVES: Low-dose aspirin is standard treatment for prevention of cardiovascular events in at-risk patients. However, long-term administration of low-dose aspirin is associated with a greater risk of adverse events, ...

Intrapleural streptokinase for empyema and complicated parapneumonic effusions

Diacon A.H.; Theron J.; Schuurmans M.M.; Van De Wal B.W.; Bolliger C.T. (2004)

We conducted a single-center, randomized, placebo-controlled trial to determine whether streptokinase instillations adjunctive to chest tube drainage reduce the need for surgery and improve outcome in patients with pleural ...

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