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Evaluating the BED capture enzyme immunoassay to estimate HIV incidence among adults in three countries in sub-Saharan Africa

Kim, A. A.; McDougal, J. S.; Hargrove, J.; Rehle, T.; Pillay-Van Wyk, V.; Puren, A.; Ekra, A.; Borget-Alloue, M. Y.; Adje-Toure, C.; Abdullahi, A. S.; Odawo, L.; Marum, L.; Parekh, B. S. (2010)

Serological assays for estimating HIV-1 incidence are prone to misclassification, limiting the accuracy of the incidence estimate. Adjustment factors have been developed and recommended for estimating assay-based HIV-1 ...

The potential to transmit Mycobacterium tuberculosis at a South African tertiary teaching hospital.

Sissolak D.; Bamford C.M.; Mehtar S. (2010)

OBJECTIVES: To assess the risk of nosocomial transmission by confirmed pulmonary tuberculosis (PTB) patients in a high TB/HIV incidence environment. METHODS: Between November 2006 and April 2007, we carried out a cross-sectional ...

Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer

Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)

SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...

Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infants

Jones C.E.; Naidoo S.; De Beer C.; Esser M.; Kampmann B.; Hesseling A.C. (2011)

Context: Altered immune responses might contribute to the high morbidity and mortality observed in human immunodeficiency virus (HIV)-exposed uninfected infants. Objective: To study the association of maternal HIV infection ...

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Fenner L.; Brinkhof M.W.G.; Keiser O.; Weigel R.; Cornell M.; Moultrie H.; Prozesky H.; Technau K.; Eley B.; Vaz P.; Pascoe M.; Giddy J.; Van Cutsem G.; Wood R.; Egger M.; Davies M.-A. (2010)

Background: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in children retained in care and in all ...

Virologic failure and second-line antiretroviral therapy in children in South Africa-the IeDEA Southern Africa collaboration

Davies M.-A.; Moultrie H.; Eley B.; Rabie H.; Van Cutsem G.; Giddy J.; Wood R.; Technau K.; Keiser O.; Egger M.; Boulle A. (2011)

Background: With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic ...

Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...

Prioritising prevention strategies for patients in antiretroviral treatment programmes in resource-limited settings

Spaar A.; Graber C.; Dabis F.; Coutsoudis A.; Bachmann L.; McIntyre J.; Schechter M.; Prozesky H.W.; Tuboi S.; Dickinson D.; Kumarasamy N.; Pujdades-Rodriquez M.; Sprinz E.; Schilthuis H.J.; Cahn P.; Low N.; Egger M. (2010)

Expanded access to antiretroviral therapy (ART) offers opportunities to strengthen HIV prevention in resource-limited settings. We invited 27 ART programmes from urban settings in Africa, Asia and South America to participate ...

Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007

Cornell M.; Grimsrud A.; Fairall L.; Fox M.P.; Van Cutsem G.; Giddy J.; Wood R.; Prozesky H.; Mohapi L.; Graber C.; Egger M.; Boulle A.; Myer L. (2010)

Objective: Little is known about the temporal impact of the rapid scale-up of large antiretroviral therapy (ART) services on programme outcomes. We describe patient outcomes [mortality, loss-to-follow-up (LTFU) and retention] ...

HIV prevention through sport: The case of the Mathare Youth Sport Association in Kenya

Delva W.; Michielsen K.; Meulders B.; Groeninck S.; Wasonga E.; Ajwang P.; Temmerman M.; Vanreusel B. (2010)

Sport has become a popular tool for HIV prevention, based on claims that it can foster life skills that are necessary to translate knowledge, attitudes and behavioural intentions into actual behaviour. Empirical evidence ...

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