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Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa

Schaaf H.S.; Marais B.J.; Hesseling A.C.; Gie R.P.; Beyers N.; Donald P.R. (2006)

Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...

Nosocomial transmission of Mycobacterium tuberculosis in kangaroo mother care units: A risk in tuberculosis-endemic areas

Heyns L.; Gie R.P.; Goussard P.; Beyers N.; Warren R.M.; Marais B.J. (2006)

Background and aim: Kangaroo mother care (KMC) has become the standard of care for low-risk preterm babies born in developing countries. However, the potential risk of nosocomial transmission of Mycobacterium tuberculosis ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Classification of drug-resistant tuberculosis in an epidemic area

Van Rie A.; Warren R.; Richardson M.; Gie R.P.; Enarson D.A.; Beyers N.; Van Helden P.D. (2000)

Background: Traditionally, patients with drug-resistant tuberculosis are classified as having acquired drug-resistant or primary drug-resistant disease on the basis of a history of previous tuberculosis treatment. Only ...

Proportion of tuberculosis transmission that takes place in households in a high-incidence area

Verver S.; Warren R.M.; Munch Z.; Richardson M.; Van Der Spuy G.D.; Borgdorff M.W.; Behr M.A.; Beyers N.; Van Helden P.D. (2004)

The prevalence of infection among household contacts of people with tuberculosis is high. This information frequently guides active case finding. We analysed DNA fingerprints of Mycobacterium tuberculosis from 765 tuberculosis ...

The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis

Goussard P.; Gie R.P.; Kling S.; Schaaf H.S.; Kritzinger F.; Andronikou S.; Beyers N.; Rossouw G.J. (2008)

Introduction: The outcome of young infants (<6 months) being ventilated for respiratory failure caused by Mycobacterium tuberculosis (MTB) has not been recorded. Patients and Methods: A descriptive study of children <6 ...

Transmission of multidrug-resistant tuberculosis

Schaaf H.S.; Van Rie A.; Gie R.P.; Beyers N.; Victor T.C.; Van Helden P.D.; Donald P.R. (2000)

Aim. To compare the Mycobacterium tuberculosis isolates of adult index cases with multidrug-resistant (MDR) tuberculosis to the isolates obtained from their child contacts. Patients and methods. A 4-year prospective study ...

Radiographic signs and symptoms in children treated for tuberculosis: Possible implications for symptom-based screening in resource-limited settings

Marais B.J.; Gie R.P.; Hesseling A.C.; Schaaf H.S.; Enarson D.A.; Beyers N. (2006)

Background: The World Health Organization advises active tracing of children younger than 5 years old in household contact with a sputum smear-positive tuberculosis index case. This study compared radiographic disease ...

Adult-type pulmonary tuberculosis in children 10-14 years of age

Marais B.J.; Gie R.P.; Hesseling A.H.; Beyers N. (2005)

We report 8 children (10-14 years of age) who were diagnosed with tuberculosis at their local primary health care clinic from July to September 2004, after routine sputum testing was extended to all children older than 10 ...

Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis

Maree F.; Hesseling A.C.; Schaaf H.S.; Marais B.J.; Beyers N.; Van Helden P.; Warren R.M.; Schoeman J.F. (2007)

OBJECTIVES: Animal studies point to increased virulence of certain mycobacterial strains, notably those of the Beijing genotype. There are limited data on mycobacterial genotypic diversity in children with tuberculous ...