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Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer

Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)

SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...

Fine-needle aspiration biopsy: A fi rst-line diagnostic procedure in paediatric tuberculosis suspects with peripheral lymphadenopathy?

Wright C.A.; Hesseling A.C.; Bamford C.; Burgess S.M.; Warren R.; Marais B.J. (2009)

OBJECTIVE: To evaluate the diagnostic yield and time to diagnosis of fi ne-needle aspiration biopsy (FNAB) vs. routine respiratory specimens collected from children with a palpable peripheral lymph node mass and symptoms ...

Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa

Schaaf H.S.; Marais B.J.; Hesseling A.C.; Gie R.P.; Beyers N.; Donald P.R. (2006)

Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...

Nosocomial transmission of Mycobacterium tuberculosis in kangaroo mother care units: A risk in tuberculosis-endemic areas

Heyns L.; Gie R.P.; Goussard P.; Beyers N.; Warren R.M.; Marais B.J. (2006)

Background and aim: Kangaroo mother care (KMC) has become the standard of care for low-risk preterm babies born in developing countries. However, the potential risk of nosocomial transmission of Mycobacterium tuberculosis ...

Diagnosing mycobacterial lymphadenitis in children using fine needle aspiration biopsy: Cytomorphology, ZN staining and autofluorescence-making more of less

Wright C.A.; Van Der Burg M.; Geiger D.; Noordzij J.G.; Burgess S.M.; Marais B.J. (2008)

Although the incidence of TB has stabilized or declined in most world regions, it is increasing in Africa, Southeast Asia, and the Eastern Mediterranean, fuelled by the HIV pandemic. More than 4,000 people died daily from ...

Tuberculosis in women and children

Marais B.J.; Gupta A.; Starke J.R.; El Sony A. (2010)

[No abstract available]

Primary and postprimary or reactivation tuberculosis: Time to revise confusing terminology?

Marais B.J.; Parker S.K.; Verver S.; Van Rie A.; Warren R.M. (2009)

[No abstract available]

A critical look at the diagnostic value of culture-confirmation in childhood tuberculosis

Engelbrecht A.L.; Marais B.J.; Donald P.R.; Schaaf H.S. (2006)

Objectives: To describe the clinical presentation, delay in diagnosis and treatment initiation, and outcome of culture-confirmed childhood tuberculosis. Methods: Retrospective study of children < 13 years of age at Tygerberg ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Improvement in mycobacterial yield and reduced time to detection in pediatric samples by use of a nutrient broth growth supplement

Brittle W.; Marais B.J.; Hesseling A.C.; Schaaf H.S.; Kidd M.; Wasserman E.; Botha T. (2009)

There is an urgent need to improve the methods used for the bacteriological diagnosis of childhood mycobacterial disease. This study compared the mycobacterial yields and the times to detection (in days) of mycobacteria ...