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Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study

Stryjewski M.E.; Chu V.H.; O'Riordan W.D.; Warren B.L.; Dunbar L.M.; Young D.M.; Vallee M.; Fowler Jr. V.G.; Morganroth J.; Barriere S.L.; Kitt M.M.; Corey G.R. (2006)

Telavancin is a bactericidal lipoglycopeptide with a multifunctional mechanism of action. We conducted a randomized, double blind, active-control phase II trial. Patients S18 years of age with complicated skin and skin ...

Diagnosing tuberculous pericarditis

Reuter H.; Burgess L.; van Vuuren W.; Doubell A. (2006)

Background: Definitive diagnosis of tuberculous pericarditis requires isolation of the tubercle bacillus from pericardial fluid, but isolating the organism is often difficult. Aim: To improve diagnostic efficiency for ...

Topiramate in the treatment of trichotillomania: An open-label pilot study

Lochner C.; Seedat S.; Niehaus D.J.H.; Stein D.J. (2006)

There is a need for an effective medication for the treatment of trichotillomania (TTM), which is an impulse control disorder characterized by chronic hair-pulling. Topiramate has shown promising results in the treatment ...

Comparison of sequential intravenous/oral ciprofloxacin plus metronidazole with intravenous ceftriaxone plus metronidazole for treatment of complicated intra-abdominal infections

Wacha H.; Warren B.; Bassaris H.; Nikolaidis P.; Vestweber K.; Pichlmayr R.; Engemann R.; Buchholz W.; Buhr H.; Von Feldmann F.; Hohenberger W.; Meister R.; Cugnenc J.; Huten N.; Chevallier J.-M.; Letoublon C.; Domergue J.; Brimas G.; Pavalkis D.; Drews M.; Buchler M.; Igra Y.; Kitzes R.; Lang R.; Solomon M.; Smith R.; Raz R.; Pfeffermann R.; Dan M.; Senninger N.; Jauch K.; Gebhardt C. (2006)

Background and Purpose: Intra-abdominal infections are a substantial clinical problem and an important cause of morbidity and death in the hospital. Optimal treatment requires both source control and antibiotic therapy. ...

The effects of eicosapentaenoic acid in tardive dyskinesia: A randomized, placebo-controlled trial

Emsley R.; Niehaus D.J.H.; Koen L.; Oosthuizen P.P.; Turner H.J.; Carey P.; van Rensburg S.J.; Maritz J.S.; Murck H. (2006)

Objective: Worldwide, conventional antipsychotic medication continues to be used extensively, and tardive dyskinesia (TD) remains a serious complication. The primary objective of the present study was to compare the efficacy ...

Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomized controlled treatment trials

Fineberg N.A.; Stein D.J.; Premkumar P.; Carey P.; Sivakumaran T.; Vythilingum B.; Seedat S.; Westenberg H.; Denys D. (2006)

Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive-compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, ...