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Nosocomial transmission of Mycobacterium tuberculosis in kangaroo mother care units: A risk in tuberculosis-endemic areas
(2006)
Background and aim: Kangaroo mother care (KMC) has become the standard of care for low-risk preterm babies born in developing countries. However, the potential risk of nosocomial transmission of Mycobacterium tuberculosis ...
Prioritising prevention strategies for patients in antiretroviral treatment programmes in resource-limited settings
(2010)
Expanded access to antiretroviral therapy (ART) offers opportunities to strengthen HIV prevention in resource-limited settings. We invited 27 ART programmes from urban settings in Africa, Asia and South America to participate ...
Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007
(2010)
Objective: Little is known about the temporal impact of the rapid scale-up of large antiretroviral therapy (ART) services on programme outcomes. We describe patient outcomes [mortality, loss-to-follow-up (LTFU) and retention] ...
HIV risk exposure among South African children in public health facilities
(2008)
The study investigates the risk exposure to HIV infection among South African children aged 2-9 years served by public health services. Together with their biological mothers, 3471 children and were recruited from inpatient ...
Change in co-receptor usage of current South African HIV-1 subtype C primary isolates
(2002)
Phenotypic analysis was performed on 13 HIV-1 strains isolated between 2000 and 2001. Syncytium-inducing and non-syncytium-inducing subtype C viruses were found, most of which used more than one co-receptor. For the first ...
Phase II trial of ZD0473 as second-line therapy in mesothelioma
(2002)
A phase II, open-label, non-comparative, multicentre trial of the platinum analogue ZD0473 as second-line therapy for pleural mesothelioma has been completed. The objectives were to evaluate the activity and tolerability ...
Esomeprazole 40 mg administered intravenously has similar safety and efficacy profiles to the oral formulation in patients with erosive esophagitis
(2004)
Background/Aims: An intravenous formulation of esomeprazole has been developed for use in patients where oral administration is not appropriate. This study evaluated safety after 1 and 4 weeks, and efficacy after 4 weeks' ...
Treatment of operable breast cancer in the elderly: A randomised clinical trial EORTC 10850 comparing modified radical mastectomy with tumorectomy plus tamoxifen
(2003)
We have examined the outcome of older patients with operable breast cancer treated in a randomised trial by either standard surgery or less extensive surgery and tamoxifen. There were 236 participants aged ≥70 years, ...
An atropine and glycopyrrolate combination reduces mortality in organophosphate poisoning
(2009)
Anticholinergics are the mainstay of the pharmacological management of organophosphate poisoning (OPP). Atropine has the potential to cause central toxicity which may complicate the management of this life-threatening ...
A study of semen parameters with emphasis on sperm morphology in a fertile population: An attempt to develop clinical thresholds
(2001)
The aim of the study was to determine the semen parameters of a proven fertile population and to compare these parameters with that of a subfertile group in the same region. Sixty-nine fertile male patients were studied ...