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Postmenopausal bleeding: A diagnostic approach for both private and public sectors

Spicer J.M.; Siebert I.; Kruger T.F. (2006)

Objective: To assess the optimal diagnostic approach to women with postmenopausal bleeding by comparing transvaginal ultrasound and endometrial sampling with office hysteroscopy. Methods: A prospective collective study was ...

Effect of fibroids on fertility in patients undergoing assisted reproduction: A structured literature review

Benecke C.; Kruger T.F.; Siebert T.I.; Van Der Merwe J.P.; Steyn D.W. (2005)

Objective: The aim of this study is to evaluate the current data to understand the impact of intramural leiomyomata on pregnancy outcome in assisted reproduction. Patients and Methods: In this review, articles were found ...

Oral ibandronate for the treatment of metastatic bone disease in breast cancer: Efficacy and safety results from a randomized, double-blind, placebo-controlled trial

Tripathy, D.; Lichinitzer, M.; Lazarev, A.; MacLachlan, S. A.; Apffelstaedt, J.; Budde, M.; Bergstrom, B.; Abdi, E.; Abramson, N.; Baker, T. M.; Kirkegaard, L. W.; Schmidt, J. R.; Bell, D.; Bell, R.; Belt, R. J.; Bernstein, J. I.; Just, R. G.; Burningham, R. A.; Trafficante, B.; Caggiano, V.; Cartwright, T.; Chernozemsky, I. N.; Clingan, P.; Conkling, P.; Craig, J. B.; Grosbach, A. B.; Decker, D.; Dickman, E.; Duga, Jr. W.; Dunlap, W.; Eisenberg, P. D.; Ellerton, J.; Ettinger, M.; Ey, F.; Falkson, G.; Falkson, C.; Fink, K.; Fleagle, J.; Forlenza, T.; Gorbunova, V. A.; Gross, G. E.; Grotes, T.; Grygiel, J.; Gudgeon, A.; Werner, I. D.; Hacking, D.; Harrer, G. W.; Harvey, V.; Hirsch, R.; Koletsky, A.; Jordaan, J. P.; Cash, D. K.; Khasanov, R. Sh.; LaFata, J. A.; Lafollette, S.; Koshla, P.; Landers, G.; Lebos, H. C.; Wade, J. L.; Lowenthal, T.; Lyons, R.; McLachlan, S. A.; Murray, R.; Perez, D.; Phadke, K.; Rapoport, B.; Rausch, P. G.; Robinson, B.; Sarna, G.; Saven, A.; Schwartz, M.; Semiglazov, V. F.; Stewart, J.; Sunderland, K.; Thomas, L.; Vogel, C. L.; Martinez Rio, M.; Vorobiof, D. A.; Wilks, S.; Woolley, P. (2004)

Background: We report the first results of a randomized trial assessing a new oral aminobisphosphonate, ibandronate, in patients with bone metastases from breast cancer. Patients and methods: Patients (n = 435) received ...

Altered plasma neurokinin B levels in patients with pre-eclampsia

Geissbuehler V.; Moser R.; Zimmermann K.; Hillermann R.; Czarniecki J.; Gebhardt S.G.; Eberhard J. (2007)

Objective(s): This study determines the levels of Neurokinin B (NKB) in the plasma of South African coloured pregnant women with and without pre-eclampsia (PE) and correlates these results with clinical data. Additionally, ...

Alendronate prevents loss of bone density associated with discontinuation of hormone replacement therapy: A randomized controlled trial

Ascott-Evans B.H.; Guanabens N.; Kivinen S.; Stuckey B.G.A.; Magaril C.H.; Vandormael K.; Stych B.; Melton M.E. (2003)

Background: Many women using hormone replacement therapy (HRT) will discontinue HRT and lose its bone-protective effect. Methods to preserve bone density in these women need to be explored. This multicenter, international, ...

A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen

Ruff P.; Vorobiof D.A.; Jordaan J.P.; Demetriou G.S.; Moodley S.D.; Nosworthy A.L.; Werner I.D.; Raats J.; Burgess L.J. (2009)

Purpose: To determine if concomitant administration of docetaxel plus zosuquidar.3HC1 can prolong progression-free survival in patients with metastatic breast cancer. Methods: A randomized, double-blind, multicenter, ...

Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial

Rosen L.S.; Gordon D.; Kaminski M.; Howell A.; Belch A.; Mackey J.; Apffelstaedt J.; Hussein M.; Coleman R.E.; Reitsma D.J.; Seaman J.J.; Chen B.-L.; Ambros Y. (2001)

PURPOSE: Zoledronic acid, a new and more potent bisphosphonate, was compared with pamidronate, the current standard treatment for patients with osteolytic or mixed bone metastases/lesions. PATIENTS AND METHODS: A total of ...

Risk of invasive cancer of the cervix in relation to the use of injectable progestogen contraceptives and combined estrogen/progestogen oral contraceptives (South Africa)

Shapiro S.; Rosenberg L.; Hoffman M.; Kelly J.P.; Cooper D.D.; Carrara H.; Denny L.E.; Du Toit G.; Allan B.R.; Stander I.A.; Williamson A.-L. (2003)

Background: Cervical cancer is caused by specific types of the human papilloma virus (HPV), but not all infected women develop cancer. It has been hypothesized that hormonal contraceptives may potentiate the oncogenicity ...

The management of tuberculous pericardial effusion: Experience in 233 consecutive patients

Reuter H.; Burgess L.J.; Louw V.J.; Doubell A.F. (2007)

Aim: We report on the 30-day and one-year outcome of consecutive effusive pericarditis patients, including those with tuberculous pericarditis, over a six-year-period. Methods and Results: Patients with large pericardial ...

Immune cell membrane fatty acids and inflammatory marker, C-reactive protein, in patients with multiple sclerosis

Hon, G.; Hassan, M.; Van Rensburg, S. J.; Abel, S.; Marais, D. W.; Van Jaarsveld, P.; Smuts, C.; Henning, F.; Erasmus, R.; Matsha, T. (2009)

Measurement of fatty acids in biological fluids and cell membranes including leucocytes from multiple sclerosis patients is inconsistent. The objective of the present study was to investigate the fatty acid composition ...

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