Search

Now showing items 31-40 of 45

Citalopram 20 mg, 40 mg and 60 mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder

Montgomery S.A.; Kasper S.; Stein D.J.; Hedegaard K.B.; Lemming O.M. (2001)

Serotonin reuptake inhibitors appear to be uniquely effective treatments for obsessive-compulsive disorder (OCD). This double-blind, placebo-controlled study was the first trial to assess the efficacy of the most selective ...

Double-blind, placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorder

Seedat S.; Stein M.B. (2004)

Background: Generalized social anxiety disorder (GSAD) is a pervasive form of social anxiety that affects approximately 5% of persons in the community. Among evidence-based pharmacologic treatments for the disorder, selective ...

Comparing axillary and mediastinal lymphadenopathy on CT in children with suspected pulmonary tuberculosis

Theron S.; Andronikou S. (2005)

Background: Radiographic demonstration of mediastinal lymphadenopathy is important for the diagnosis of pulmonary tuberculosis (PTB). Plain radiographs are unreliable for this and CT, which is relatively more expensive and ...

Comparison of sequential intravenous/oral ciprofloxacin plus metronidazole with intravenous ceftriaxone plus metronidazole for treatment of complicated intra-abdominal infections

Wacha H.; Warren B.; Bassaris H.; Nikolaidis P.; Vestweber K.; Pichlmayr R.; Engemann R.; Buchholz W.; Buhr H.; Von Feldmann F.; Hohenberger W.; Meister R.; Cugnenc J.; Huten N.; Chevallier J.-M.; Letoublon C.; Domergue J.; Brimas G.; Pavalkis D.; Drews M.; Buchler M.; Igra Y.; Kitzes R.; Lang R.; Solomon M.; Smith R.; Raz R.; Pfeffermann R.; Dan M.; Senninger N.; Jauch K.; Gebhardt C. (2006)

Background and Purpose: Intra-abdominal infections are a substantial clinical problem and an important cause of morbidity and death in the hospital. Optimal treatment requires both source control and antibiotic therapy. ...

Effect of HIV infection status and Anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants

Madhi S.A.; Adrian P.; Cotton M.F.; McIntyre J.A.; Jean-Philippe P.; Meadows S.; Nachman S.; Kayhty H.; Klugman K.P.; Violari A. (2010)

Serotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4+ ...

Reboxetine and citalopram in panic disorder: A single-blind, cross-over, flexible-dose pilot study

Seedat S.; Van Oudtshoorn E.V.R.; Muller J.E.; Mohr N.; Stein D.J. (2003)

Both noradrenergic and serotonergic systems have been implicated in the pathophysiology of panic disorder. The advent of selective serotonin (5-HT) reuptake inhibitors (SSRIs) (e.g. citalopram) and, more recently, selective ...

A comparison of the effects of quetiapine ('Seroquel') and haloperidol in schizophrenic patients with a history of and a demonstrated, partial response to conventional antipsychotic treatment

Emsley R.A.; Raniwalla J.; Bailey P.J.; Jones A.M. (2000)

Quetiapine ('Seroquel') is a well-tolerated, novel, atypical antipsychotic with consistent efficacy in the treatment of schizophrenia. To date, no clinical studies have evaluated the effect of quetiapine in patients who ...

Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trialRecombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial

Opal, S.; Laterre, P-F.; Abraham, E.; Francois, B.; Wittebole, X.; Lowry, S.; Dhainaut, J-F.; Warren, B.; Dugernier, T.; Lopez, A.; Sanchez, M.; Demeyer, I.; Jauregui, L.; Lorente, J. A.; McGee, W.; Reinhart, K.; Kljucar, S.; Souza, S.; Pribble, J.; Opal, S.; Laterre, P-F.; Abraham, E.; Francois, B.; Wittebole, X.; Lowry, S.; Dhainaut, J-F.; Warren, B.; Dugernier, T.; Lopez, A.; Sanchez, M.; Demeyer, I.; Jauregui, L.; Lorente, J. A.; McGee, W.; Reinhart, K.; Kljucar, S.; Souza, S.; Pribble, J. (2004)

Objective: Platelet-activating factor (PAF) and structurally-related oxidized phospholipids are proinflammatory mediators in systemic inflammatory states such as severe sepsis. The enzyme platelet-activating factor ...

Changes in erythrocyte membrane fatty acids during a clinical trial of eicosapentaenoic acid (EPA) supplementation in schizophrenia

Van Rensburg, S. J.; Smuts, C. M.; Hon, D.; Kidd, M.; Van Der Merwe, S.; Myburgh, C.; Oosthuizen, P.; Emsley, R. (2009)

In a previously reported double-blind, placebo-controlled trial of eicosapentaenoic acid (EPA) as supplemental treatment in 40 patients with schizophrenia, we found significant improvement in symptoms as measured by the ...

Antiretroviral treatment for children with peripartum nevirapine exposure

Palumbo, P.; Lindsey, J. C.; Hughes, M. D.; Cotton, M. F.; Bobat, R.; Meyers, T.; Bwakura-Dangarembizi, M.; Chi, B. H.; Musoke, P.; Kamthunzi, P.; Schimana, W.; Purdue, L.; Eshleman, S. H.; Abrams, E. J.; Millar, L.; Petzold, E.; Mofenson, L. M.; Jean-Philippe, P.; Violari A. (2010)

Background: Single-dose nevirapine is the cornerstone of the regimen for prevention of mother-to-child transmission of human immunodeficiency virus (HIV) in resource-limited settings, but nevirapine frequently selects for ...