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Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer

Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)

SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...

Fine-needle aspiration biopsy: A fi rst-line diagnostic procedure in paediatric tuberculosis suspects with peripheral lymphadenopathy?

Wright C.A.; Hesseling A.C.; Bamford C.; Burgess S.M.; Warren R.; Marais B.J. (2009)

OBJECTIVE: To evaluate the diagnostic yield and time to diagnosis of fi ne-needle aspiration biopsy (FNAB) vs. routine respiratory specimens collected from children with a palpable peripheral lymph node mass and symptoms ...

Management of life-threatening haemoptysis in an area of high tuberculosis incidence

Gross A.M.; Diacon A.H.; Van Den Heuvel M.M.; Van Rensburg J.; Harris D.; Bolliger C.T. (2009)

BACKGROUND: Emergency admissions with life-threatening haemoptysis in an area of high tuberculosis (TB) incidence at the University of Stellenbosch and Tygerberg Academic Hospital, South Africa. It is unclear if lung ...

The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions

Zemlin A.E.; Burgess L.J.; Carstens M.E. (2009)

SETTING: Pleural adenosine deaminase (ADA) levels have been found to be useful in diagnosing tuberculous pleuritis. Elevated ADA levels have been attributed to ADA2 isoenzyme, although no comprehensive studies have evaluated ...

Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

Cotton M.F.; Schaaf H.S.; Lottering G.; Weber H.L.; Coetzee J.; Nachman S. (2008)

Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, ...

Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infants

Jones C.E.; Naidoo S.; De Beer C.; Esser M.; Kampmann B.; Hesseling A.C. (2011)

Context: Altered immune responses might contribute to the high morbidity and mortality observed in human immunodeficiency virus (HIV)-exposed uninfected infants. Objective: To study the association of maternal HIV infection ...

Cytokine production in patients with tuberculous pericarditis

Burgess L.J.; Reuter H.; Carstens M.E.; Taljaard J.J.F.; Doubell A.F. (2002)

SETTING: An academic hospital in the Western Cape, South Africa. OBJECTIVE: To evaluate cytokine production (interferon-gamma [IFN-γ], interleukin-1 [IL-1], interleukin-2 [IL-2], interleukin-6 [IL-6], interleukin-10 [IL-10], ...

Can uroflowmetry patterns in women be reliably interpreted?

Chou T.-P.; Gorton E.; Stanton S.L.; Atherton M.; Baessler K.; Rienhardt G. (2000)

Our aim was to investigate the proposition that uroflowmetry patterns can be reliably interpreted and correspond with specific urodynamic diagnoses. Uroflowmetry traces from 129 women with diagnoses of either genuine stress ...

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Fenner L.; Brinkhof M.W.G.; Keiser O.; Weigel R.; Cornell M.; Moultrie H.; Prozesky H.; Technau K.; Eley B.; Vaz P.; Pascoe M.; Giddy J.; Van Cutsem G.; Wood R.; Egger M.; Davies M.-A. (2010)

Background: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in children retained in care and in all ...

Virologic failure and second-line antiretroviral therapy in children in South Africa-the IeDEA Southern Africa collaboration

Davies M.-A.; Moultrie H.; Eley B.; Rabie H.; Van Cutsem G.; Giddy J.; Wood R.; Technau K.; Keiser O.; Egger M.; Boulle A. (2011)

Background: With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic ...

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