Now showing items 11-20 of 530
Ethionamide cross-and co-resistance in children with isoniazid-resistant tuberculosis
BACKGROUND: Ethionamide (ETH) is a structural analogue of isoniazid (INH). Both are pro-drugs requiring activation by separate and common enzyme pathways, which could lead to co-and/or cross-resistance. OBJECTIVE: To ...
Fine needle aspiration biopsy: An undervalued diagnostic modality in paediatric mycobacterial disease
Mycobacterial disease, and particularly tuberculosis (TB), is an escalating problem in developing countries, fuelled by the parallel human immunodeficiency virus (HIV) pandemic. In TB endemic countries children carry a ...
Fine-needle aspiration biopsy: A fi rst-line diagnostic procedure in paediatric tuberculosis suspects with peripheral lymphadenopathy?
OBJECTIVE: To evaluate the diagnostic yield and time to diagnosis of fi ne-needle aspiration biopsy (FNAB) vs. routine respiratory specimens collected from children with a palpable peripheral lymph node mass and symptoms ...
Management of life-threatening haemoptysis in an area of high tuberculosis incidence
BACKGROUND: Emergency admissions with life-threatening haemoptysis in an area of high tuberculosis (TB) incidence at the University of Stellenbosch and Tygerberg Academic Hospital, South Africa. It is unclear if lung ...
The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions
SETTING: Pleural adenosine deaminase (ADA) levels have been found to be useful in diagnosing tuberculous pleuritis. Elevated ADA levels have been attributed to ADA2 isoenzyme, although no comprehensive studies have evaluated ...
Risk factors for recurrence of haemoptysis following bronchial artery embolisation for life-threatening haemoptysis
SETTING: Life-threatening haemoptysis is a frequent and often fatal complication in areas with a high prevalence of tuberculosis (TB). Bronchial artery embolisation remains the standard initial treatment. Subsequent curative ...
What new knowledge did we gain through The International Journal of Tuberculosis and Lung Disease in 2007?
[No abstract available]
Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting
Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, ...
What new knowledge did we gain through the International Journal of Tuberculosis and Lung Disease in 2006?
[No abstract available]
The assessment of new anti-tuberculosis drugs for a paediatric indication
For the first time in three decades there is a promising pipeline of more than 20 new anti-tuberculosis agents at various stages of development, and several are already entering early clinical trials. Childhood tuberculosis ...