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Stability of Polymorphic GC-Rich Repeat Sequence-Containing Regions of Mycobacterium tuberculosis
Mycobacterium tuberculosis cultures were subjected to DNA fingerprinting with IS6110- and polymorphic GC-rich sequence (PGRS)-containing probes. The PGRS banding patterns remained highly stable during multiple cultures of ...
Molecular Characteristics and Global Spread of Mycobacterium tuberculosis with a Western Cape F11 Genotype
In order to fully understand the global tuberculosis (TB) epidemic it is important to investigate the population structure and dissemination of the causative agent that drives the epidemic. Mycobacterium tuberculosis strain ...
Clonal expansion of a globally disseminated lineage of Mycobacterium tuberculosis with low IS6110 copy numbers
Knowledge of the clonal expansion of Mycobacterium tuberculosis and accurate identification of predominant evolutionary lineages in this species remain limited, especially with regard to low-IS6110-copy-number strains. In ...
Genomic characterization of an endemic Mycobacterium tuberculosis strain: Evolutionary and epidemiologic implications
In a study of 302 Mycobacterium tuberculosis clinical isolates from the low-incidence Canadian-born population of Quebec, we characterized a large endemic strain family by using genomic deletions. The DS6Quebec deleted ...
Transposition rates of Mycobacterium tuberculosis IS6110 restriction fragment length polymorphism patterns
To determine the rate at which IS1160 restriction fragment length polymorphism (RFLP) patterns in Mycobacterium tuberculosis change over time, we applied a smooth nonparametric survival model to several data sets, including ...