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Stability of Polymorphic GC-Rich Repeat Sequence-Containing Regions of Mycobacterium tuberculosis
Mycobacterium tuberculosis cultures were subjected to DNA fingerprinting with IS6110- and polymorphic GC-rich sequence (PGRS)-containing probes. The PGRS banding patterns remained highly stable during multiple cultures of ...
Clonal expansion of a globally disseminated lineage of Mycobacterium tuberculosis with low IS6110 copy numbers
Knowledge of the clonal expansion of Mycobacterium tuberculosis and accurate identification of predominant evolutionary lineages in this species remain limited, especially with regard to low-IS6110-copy-number strains. In ...
Transposition rates of Mycobacterium tuberculosis IS6110 restriction fragment length polymorphism patterns
To determine the rate at which IS1160 restriction fragment length polymorphism (RFLP) patterns in Mycobacterium tuberculosis change over time, we applied a smooth nonparametric survival model to several data sets, including ...
IS6110-Mediated Deletion Polymorphism in Isogenic Strains of Mycobacterium tuberculosis
Previous studies have described IS6110-mediated polymorphism as an important driving force in Mycobacterium tuberculosis genome evolution and have provided indirect evidence for IS6110-driven deletion events. This study ...