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Esomeprazole 40 mg administered intravenously has similar safety and efficacy profiles to the oral formulation in patients with erosive esophagitis

Schneider, H.; Van Rensburg, C.; Schmidt, S.; Aboo, N.; Makela, H.; Naucler, E.; Hallerback, B.; Svedberg, L-E. (2004)

Background/Aims: An intravenous formulation of esomeprazole has been developed for use in patients where oral administration is not appropriate. This study evaluated safety after 1 and 4 weeks, and efficacy after 4 weeks' ...

Pharmacodynamic equivalence of a decapeptyl 3-month SR formulation with the 28-day SR formulation in patients with advanced prostate cancer

Teillac P.; Heyns C.F.; Kaisary A.V.; Bouchot O.; Blumberg J. (2004)

Aims: The objective of the study was to assess the pharmacodynamic equivalence of LHRH analogue triptorelin 3-month and 28-day SR formulations. Methods: Patients with documented locally advanced or metastatic prostate ...

Left Cardiac Sympathetic Denervation in the Management of High-Risk Patients Affected by the Long-QT Syndrome

Schwartz P.J.; Priori S.G.; Cerrone M.; Spazzolini C.; Odero A.; Napolitano C.; Bloise R.; De Ferrari G.M.; Klersy C.; Moss A.J.; Zareba W.; Robinson J.L.; Hall W.J.; Brink P.A.; Toivonen L.; Epstein A.E.; Li C.; Hu D. (2004)

Background - The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in ...

Can CT predict the level of CSF block in tuberculous hydrocephalus?

Bruwer G.E.; Van der Westhuizen S.; Lombard C.J.; Schoeman J.F. (2004)

Introduction: Treatment of obstructive hydrocephalus in children with tuberculous meningitis (TBM) depends on the level of the cerebrospinal fluid (CSF) block. Air-encephalography is regarded as the gold standard for ...

Efficacy and safety of pantoprazole versus ranitidine in the treatment of patients with symptomatic gastroesophageal reflux disease

Van Zyl J.; Van Rensburg C.; Vieweg W.; Fischer R. (2004)

Background/Aim: Gastroesophageal reflux disease (GERD) is a prevalent disease associated with a high symptom burden and a reduced quality of life. This multicenter, randomized, double-blind study compared relief from key ...

Intrapleural streptokinase for empyema and complicated parapneumonic effusions

Diacon A.H.; Theron J.; Schuurmans M.M.; Van De Wal B.W.; Bolliger C.T. (2004)

We conducted a single-center, randomized, placebo-controlled trial to determine whether streptokinase instillations adjunctive to chest tube drainage reduce the need for surgery and improve outcome in patients with pleural ...

Expression, purification, biochemical and pharmacological characterization of a recombinant aprotinin variant

Apeler H.; Peters J.; Schroder W.; Schneider K.-H.; Lemm G.; Hinz V.; Rossouw G.J.; Dembowsky K. (2004)

Aprotinin (CAS 9087-70-1) is known as a potent inhibitor of serine proteases such as trypsin, plasmin, tissue and plasma kallikrein. In this study, an aprotinin variant was designed by means of rationale mutagenesis that ...

Specificity and sensitivity of chest radiographs in the diagnosis of paediatric pulmonary tuberculosis and the value of additional high-kilovolt radiographs

De Villiers R.V.P.; Andronikou S.; Van De Westhuizen S. (2004)

Tuberculosis (TB) remains the most common notifiable infectious disease in South Africa. The diagnosis of pulmonary TB in children is often very difficult because of the non-specific radiological signs and inter-observer ...

Human metapneumovirus infection in hospital referred South African children

Ijpma, F. F. A.; Beekhuis, D.; Cotton, M. F.; Pieper, C. H.; Kimpen, J. L. L.; Van Den Hoogen, B. G.; Van Doornum, G. J. J.; Osterhaus, D. M. E. (2004)

Human metapneumovirus (hMPV) was first described in Dutch children with acute respiratory symptoms. A prospective analysis of the epidemiology, clinical manifestation, and seroprevalence of hMPV and other respiratory viruses ...

Use of Studded Polyflex™ Stents in Patients with Neoplastic Obstructions of the Central Airways

Bolliger C.T.; Breitenbuecher A.; Brutsche M.; Heitz M.; Stanzel F. (2004)

Background: The Polyflex™ is a commercially available silastic airway stent with proven efficacy. Due to a smooth outer surface its anchorage in the airway wall is superficial which may lead to stent migration. Objective: ...