Now showing items 1-10 of 255
Value of different staging systems for predicting neurological outcome in childhood tuberculous meningitis
BACKGROUND: The stage of tuberculous meningitis (TBM) at presentation is strongly associated with prognosis. OBJECTIVE: To compare different staging systems for TBM in predicting outcome. METHODS: The associations of ...
Surveillance of transmitted resistance to antiretroviral drug classes among young children in the western cape province of SOUTH AFRICA
There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants ...
Localized basal meningeal enhancement in tuberculous meningitis
Background: Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM). Objective: To demonstrate the incidence, distribution and appearance of localized ...
Pyrazinamide plasma concentrations in young children with tuberculosis
Pyrazinamide plasma concentrations were determined in 34 children (median age, 3.32 years) 1 month after commencing antituberculosis treatment. The median (interquartile range) peak concentration was 30.7 (25.5, 35.0) mg/L ...
Molecular detection of mixed infections of Mycobacterium tuberculosis strains in sputum samples from patients in Karonga District, Malawi
The occurrence of mixed infections of Mycobacterium tuberculosis is no longer disputed. However, their frequency, and the impact they may have on our understanding of tuberculosis (TB) pathogenesis and epidemiology, remains ...
High-dose intense chemotherapy in South African children with B-cell lymphoma: Morbidity, supportive measures, and outcome
Background. Twenty-five percent of South African children aged 6-71 months are undernourished and have stunted growth. The tolerance and efficacy of short, high-dose intense chemotherapy for B-cell lymphomas in such a ...
Long term survival of children with burkitt lymphoma in Malawi after cyclophosphamide monotherapy
Background. Between 1991 and 1997, limited funding at times restricted available treatment for children with Burkitt lymphoma (BL) to cyclophosphamide (CPM) monotherapy at Lilongwe Central Hospital, Malawi. Our objective ...
Improvement in mycobacterial yield and reduced time to detection in pediatric samples by use of a nutrient broth growth supplement
There is an urgent need to improve the methods used for the bacteriological diagnosis of childhood mycobacterial disease. This study compared the mycobacterial yields and the times to detection (in days) of mycobacteria ...
An update on bronchopulmonary dysplasia: Is there a relationship to the development of childhood asthma?
There appears to be some interesting commonalities between asthma and BPD. The prevalence of both conditions is on the rise, both conditions tend to cluster in families, and they share wheezing phenotypes, i.e., mild-moderate ...
Children and tuberculosis: Protecting the next generation?
[No abstract available]