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Isoniazid-mediated irreversible inhibition of the myeloperoxidase antimicrobial system of the human neutrophil and the effect of thyronines

Van Zyl J.M. Basson K. Uebel R.A. Van der Walt B.J. (1989)

During aerobic myeloperoxidase-catalysed oxidation of isoniazid at pH 7.8, compound III was generated. Oxidation of isoniazid or hydrazine sulphate at pH valu7es of 6.5 or 7.8 in a myeloperoxidase-H2O2 system caused ...