University Centres and Units
Sub-communities within this community
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Other Institutes / Centres / Divisions / Services194
Institutes / Centres / Divisions that are universal to the campus research community. -
Work in Progress33914
These are items that are in the process of being catalogued and moved to specific departmental collections.
Recent Submissions
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Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa
(Nature Publishing Group, 2018)HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations (RAMs) against ...
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Shorter treatment for minimal tuberculosis (TB) in children (SHINE) : a study protocol for a randomised controlled trial
(BioMed Central, 2018-04-19)Background: Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. Trials ...
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Examination of the roles and capacities of duty bearers responsible for protecting the human rights to adequate food, nutritional health and wellbeing in Ugandan children’s homes
(BioMed Central, 2018-04-17)Background: The majority of Ugandan children face vulnerability and malnutrition. As a State Party to international human rights treaties, Uganda has legal obligations of guaranteeing the fundamental rights and the best ...
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Evolution of computational models in BioModels Database and the Physiome Model Repository
(BioMed Central, 2018-04-12)Background: A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and refined. Even ...
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Common mental disorders and psychological adjustment among individuals seeking HIV testing : a study protocol to explore implications for mental health care systems
(BioMed Central, 2018-04-10)Background: In an effort to promote greater access to voluntary counseling and testing for HIV, it has become practice in many countries, including South Africa, to establish non-medical testing sites and to de-couple HIV ...
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Caregiver experiences of public services following child trauma exposure : a qualitative study
(BioMed Central, 2018-04-10)Background: Many children in low and middle income countries (LMIC) are exposed to trauma. Contact with public services are a potential influence on parent–child reactions and coping post-trauma. Little is known about how ...
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Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)
(BioMed Central, 2018-04-10)Background: Cancer and inflammation are associated with cachexia. Withania somnifera (W. somnifera) possesses antioxidant and anti-inflammatory potential. We investigated the potential of an aqueous extract of the root ...
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Exploring the South African tax consequences of a residential property lottery
(AOSIS Publishing, 2018)Background: Disposing of a residential property by way of a lottery sounds peculiar, but a number of these transactions relating to residential properties in South Africa have recently taken place. As this is not an ordinary ...
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What are the indicators of a successful business rescue in South Africa? ask the business rescue practitioners
(AOSIS Publishing, 2018)Background: Business rescue, in terms of Chapter 6 of the Companies Act No 71 of 2008, is still relatively new to the South African business environment. The need for a successful business rescue regime is beyond doubt. ...
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Die ontwikkeling van ekogeletterdheid deur middel van ’n Afrikaanse leesreeks
(LitNet, 2017)Hierdie artikel is ’n waarderende refleksie op ’n leesreeks wat spesifiek vir ekologiese opvoeding ontwikkel is. Die tekste in die reeks beskik oor die potensiaal om by kinders ’n dieper kennis van die ekostelsel te ...
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Homework policy review : a case study of a public school in the Western Cape Province
(Education Association of South Africa, 2018)A key concern today is the question of homework in our nation’s public schools. In this study, an investigation was conducted with the first no-homework policy, which has been introduced in one of the primary schools in ...
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Metabolic syndrome and body shape predict differences in health parameters in farm working women
(BioMed Central, 2018-04-04)Background: Sufficient evidence associate body shape to detrimental lifestyle diseases including the metabolic syndrome (MetS). The prevalence of the MetS, as well as effects of the MetS and body shape on body ...
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Spatial distribution of leprosy in India : an ecological study
(BioMed Central, 2018-03-27)Background: As leprosy elimination becomes an increasingly realistic goal, it is essential to determine the factors that contribute to its persistence. We evaluate social and economic factors as predictors of leprosy ...
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A comparative analysis of pharmacists’ perspectives on codeine use and misuse – a three country survey
(BioMed Central, 2018-03-27)Background: The misuse of codeine is of increasing concern in a number of countries, particularly as this relates to over -the-counter pain and cough relief medication, and is also supplied as a prescription medicine. The ...
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Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD
(BioMed Central, 2018-03-27)Objective: The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known in certain studies while that of the post tuberculosis form is not yet known. This study aimed to evaluate ...
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Nurse led home-based care for people with HIV/AIDS
(BioMed Central, 2018-03-27)Background: Home-based care is used in many countries to increase quality of life and limit hospital stay, particularly where public health services are overburdened. Home-based care objectives for HIV/AIDS can include medical ...
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Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study
(BioMed Central, 2018-03-28)Background: Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of predisposing factors and the natural history ...
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Partner age differences and associated sexual risk behaviours among adolescent girls and young women in a cash transfer programme for schooling in Malawi
(BioMed Central, 2018-03-27)Background: Age disparities in sexual relationships have been proposed as a key risk factor for HIV transmission in Sub-Saharan Africa, but evidence remains inconclusive. The SIHR study, a cluster randomised trial of a ...
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Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children
(BioMed Central, 2018-03-23)Background: Tuberculosis (TB) in young and HIV-infected children is frequently diagnosed at hospital level. In settings where general hospitals do not function as TB reporting units, the burden and severity of childhood ...
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A multi-level researcher development framework to address contrasting views of student research challenges
(HESA, 2018)Ensuring quality and completion of students’ research places pressure on postgraduate supervisors. Postgraduate students’ primary interest in theoretical and practical knowledge rather than research, influences the completion ...
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Resistance and dissonance in higher education : on doing things differently
(HESA, 2018)The historical inequalities and imbalances, so deeply embedded in the institutional structures and discourse of higher education, continue to haunt university spaces as these institutions continue to veer along the precipice ...
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A comparative evaluation of PDQ-Evidence
(BioMed Central, 2018-03-15)A strategy for minimising the time and obstacles to accessing systematic reviews of health system evidence is to collect them in a freely available database and make them easy to find through a simple ‘Google-style’ search ...
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Combining uncertainties in a court of law using Bayesian networks
(Obiter Law Journal: Nelson Mandela Metropolitan University (NMMU), Faculty of Law, 2017)People generally have difficulty dealing with the counter-intuitive notion of probability, and therefore they often misunderstand aspects of uncertainty. This is particularly significant in a court of law when for example ...
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Parents as partners : building collaborations to support the development of school readiness skills in under-resourced communities
(Education Association of South Africa, 2013)The purpose of this paper is to present a preliminary, qualitative review of a therapeutic programme for preschool children and their parents in severely under-resourced contexts to aid the development of the underlying ...
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The impact of single amino acids on growth and volatile aroma production by Saccharomyces cerevisiae strains
(Frontiers Media, 2017)Nitrogen availability and utilization by Saccharomyces cerevisiae significantly influence fermentation kinetics and the production of volatile compounds important for wine aroma. Amino acids are the most important nitrogen ...
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The inflammatory effects of TNF-α and complement component 3 on coagulation
(Nature Publishing Group, 2018)Tissue necrosis factor-α (TNF-α) and complement component 3 (C3) are two well-known pro-inflammatory molecules. When TNF-α is upregulated, it contributes to changes in coagulation and causes C3 induction. They both interact ...
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Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease
(Public Library of Science, 2018)The thrombin-induced polymerisation of fibrinogen to form fibrin is well established as a late stage of blood clotting. It is known that Parkinson’s Disease (PD) is accompanied by dysregulation in blood clotting, but it ...
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Substance use and self-harm : a cross-sectional study of the prevalence, correlates and patterns of medical service utilisation among patients admitted to a South African hospital
(BioMed Central, 2018-03-06)Background: Substance use is a potentially modifiable risk factor for suicidal behaviour. Little is known about the epidemiology of substance use among self-harm patients in South Africa. This study set out to collect ...
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The relationship between childhood adversity, recent stressors, and depression in college students attending a South African university
(BioMed Central, 2018-03-09)Background: College students are at risk of depression. This risk may be increased by the experience of childhood adversity and/or recent stressors. This study examined the association between reported experiences of ...
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Rules of engagement : perspectives on stakeholder engagement for genomic biobanking research in South Africa
(BioMed Central, 2018-02-27)Background: Genomic biobanking research is undergoing exponential growth in Africa raising a host of legal, ethical and social issues. Given the scientific complexity associated with genomics, there is a growing recognition ...
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