Browsing Department of Physiological Sciences by Title

Now showing items 116-120 of 120

    • Toxic mitochondrial effects induced by "red devil" chemotherapy 

      Opperman, Caleigh Margaret (Stellenbosch : Stellenbosch University, 2015-04)
      ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX), infamously known as the “red devil,” is considered the most effective antineoplastic drug utilized in oncologic practice today. However, its clinical use is hampered due ...

    • Treading the tightrope of healthy living : pondering heart metabolism's balancing act 

      Essop, Faadiel (Stellenbosch : Stellenbosch University, 2011-09)
      Prof Faadiel Essop is the current chairperson of the Depart - ment of Physiological Sciences at Stellenbosch University. He hails from a strong rural background; he was born in Ceres and grew up in Paarl (Western Cape, ...

    • Trimetazidine therapy for diabetic mouse hearts subjected to ex vivo acute heart failure 

      Breedt, Emilene; Lacerda, Lydia; Essop, M. Faadiel (Public Library of Science, 2017-06-20)
      Acute heart failure (AHF) is the most common primary diagnosis for hospitalized heart diseases in Africa. As increased fatty acid β-oxidation (FAO) during heart failure triggers detrimental effects on the myocardium, we ...

    • The (un)SAFE and RISK(y) sides of doxorubicin-induced cardiotoxicity 

      Goldswain, Toni Leigh (Stellenbosch : Stellenbosch University, 2014-12)
      ENGLISH ABSTRACT: Introduction The discovery of Doxorubicin in the 1960s has drastically improved the survival rates of cancer patients, however, its success is limited by dose-dependent cardiotoxicity. While much of the ...

    • The variability of autophagy and cell death susceptibility : unanswered questions 

      Loos, Ben; Engelbrecht, Anna-Mart; Lockshin, Richard A.; Klionsky, Daniel J.; Zakeri, Zahra (Landes Bioscience, 2013-09)
      Impaired autophagic machinery is implicated in a number of diseases such as heart disease, neurodegeneration and cancer. A common denominator in these pathologies is a dysregulation of autophagy that has been linked to a ...