Browsing Department of Physiological Sciences by Title

Now showing items 80-83 of 83

  • Toxic mitochondrial effects induced by "red devil" chemotherapy 

    Opperman, Caleigh Margaret (Stellenbosch : Stellenbosch University, 2015-04)
    ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX), infamously known as the “red devil,” is considered the most effective antineoplastic drug utilized in oncologic practice today. However, its clinical use is hampered due ...

  • Treading the tightrope of healthy living : pondering heart metabolism's balancing act 

    Essop, Faadiel (Stellenbosch : Stellenbosch University, 2011-09)
    Prof Faadiel Essop is the current chairperson of the Depart - ment of Physiological Sciences at Stellenbosch University. He hails from a strong rural background; he was born in Ceres and grew up in Paarl (Western Cape, ...

  • The (un)SAFE and RISK(y) sides of doxorubicin-induced cardiotoxicity 

    Goldswain, Toni Leigh (Stellenbosch : Stellenbosch University, 2014-12)
    ENGLISH ABSTRACT: Introduction The discovery of Doxorubicin in the 1960s has drastically improved the survival rates of cancer patients, however, its success is limited by dose-dependent cardiotoxicity. While much of the ...

  • The variability of autophagy and cell death susceptibility : unanswered questions 

    Loos, Ben; Engelbrecht, Anna-Mart; Lockshin, Richard A.; Klionsky, Daniel J.; Zakeri, Zahra (Landes Bioscience, 2013-09)
    Impaired autophagic machinery is implicated in a number of diseases such as heart disease, neurodegeneration and cancer. A common denominator in these pathologies is a dysregulation of autophagy that has been linked to a ...