Browsing Department of Physiological Sciences by Title

Now showing items 145-148 of 148

    • The (un)SAFE and RISK(y) sides of doxorubicin-induced cardiotoxicity 

      Goldswain, Toni Leigh (Stellenbosch : Stellenbosch University, 2014-12)
      ENGLISH ABSTRACT: Introduction The discovery of Doxorubicin in the 1960s has drastically improved the survival rates of cancer patients, however, its success is limited by dose-dependent cardiotoxicity. While much of the ...

    • Utilising autophagy modulation to combat cell death resistance in Glioblastoma Multiforme 

      Kriel, Jurgen Andries (Stellenbosch : Stellenbosch University, 2016-12)
      ENGLISH SUMMARY: Introduction: Globally, Glioblastoma Multiforme (GBM) presents as both the most prevalent and invasive form of Central Nervous System (CNS) malignancy. Patient life expectancy has remained largely unchanged ...

    • The variability of autophagy and cell death susceptibility : unanswered questions 

      Loos, Ben; Engelbrecht, Anna-Mart; Lockshin, Richard A.; Klionsky, Daniel J.; Zakeri, Zahra (Landes Bioscience, 2013-09)
      Impaired autophagic machinery is implicated in a number of diseases such as heart disease, neurodegeneration and cancer. A common denominator in these pathologies is a dysregulation of autophagy that has been linked to a ...

    • Was the evolutionary road towards adaptive immunity paved with endothelium? 

      Van Niekerk, Gustav; Davis, Tanja; Engelbrecht, Anna-Mart (BioMed Central, 2015)
      Background: The characterization of a completely novel adaptive immune system (AIS) in jawless vertebrates (hagfish and lampreys) presents an excellent opportunity for exploring similarities and differences in design principles. ...