Department of Physiological Sciences
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Decreased efficacy of doxorubicin corresponds with modifications in lipid metabolism markers and fatty acid profiles in breast tumors from obese vs. lean mice
(Frontiers Media, 2018-03-17)Breast cancer cells modulate lipid and fatty acid metabolism to sustain proliferation. The role of adipocytes in cancer treatment efficacy remains, however, to be fully elucidated. We investigated whether diet-induced ... -
Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics
(Nature Research, 2018-07-09)Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation ... -
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus
(Nature Research, 2018-11-14)Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically ... -
Influence of maternal inflammation on immune modulation
(Stellenbosch : Stellenbosch University, 2020-04)ENGLISH ABSTRACT: Perturbations within intrauterine microenvironment, due to maternal stressors such as chronic inflammation, metabolic dysfunction and psychological stress, can result in lifelong detrimental consequences ... -
The role of DHEA in the aetiology of modern chronic disease
(Stellenbosch : Stellenbosch University, 2020-04)ENGLISH ABSTRACT: Dehydroepiandrosterone (DHEA) is an androgenic steroid predominantly viewed as the main precursor to androgen and estrogen hormones in the human body. DHEA exists as a sulphated ester known as DHEAS, which ... -
Manipulation of macrophage phagocytosis - development of an endogenous delivery system
(Stellenbosch : Stellenbosch University, 2020-04)ENGLISH ABSTRACT: The need to administer more potent antimicrobial drugs is supported by the ever-increasing incidence of multidrug resistance. Given the (necessary) higher toxicity of these drugs, administration into host ... -
Interleukin-6 Induces myogenic differentiation via JAK2-STAT3 signaling in mouse C2C12 myoblast cell line and primary human myoblasts
(MDPI, 2019-10-24)Postnatal muscle growth and exercise- or injury-induced regeneration are facilitated by myoblasts. Myoblasts respond to a variety of proteins such as cytokines that activate various signaling cascades. Cytokines belonging ... -
Chemoresistance in a breast cancer animal model: the role of obesity and inflammation
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Background: Globally an increase in obesity incidence represent a major health concern amongst a rising incidence of impaired treatment outcomes of breast cancer patients. Adipose tissue and/or adipocytes, ... -
The potential of LPS-binding protein to reverse amyloid formation in plasma fibrin of individuals with Alzheimer-type dementia
(Frontiers Media, 2018-08-22)Many studies indicate that there is a (mainly dormant) microbial component in the progressive development of Alzheimer-type dementias (ADs); and that in the case of Gram-negative organisms, a chief culprit might be the ... -
Chronic gestational inflammation : transfer of maternal adaptation over two generations of progeny
(Hindawi, 2019-08-25)Changes in the in utero environment result in generational transfer of maladapted physiology in the context of conditions such as stress, obesity, and anxiety. Given the significant contribution of noncommunicable ... -
Investigating the amyloidogenic potential of serum amyloid a in type ii diabetes mellitus
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Introduction: Type II Diabetes Mellitus (T2DM) is a non-communicable disease associated with chronic low-grade inflammation and persistent activation of the acute phase response (APR). Serum amyloid A ... -
The role of lipoteichoic acid on amyloidogenesis and its effect on erythrocytes and platelets
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Hypercoagulation and amyloidogenesis are commonly known as hallmarks for inflammation. Hypercoagulation and amyloidogenesis are linked to quite a few communicable and non-communicable ailments such as ... -
Redox status and muscle pathology in rheumatoid arthritis : insights from various rat hindlimb muscles
(Hindawi, 2019-03-26)Due to atrophy, muscle weakness is a common occurrence in rheumatoid arthritis (RA). The majority of human studies are conducted on the vastus lateralis muscle—a muscle with mixed fiber type—but little comparative data ... -
Rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) : from bush teas to potential therapy for cardiovascular disease
(IntechOpen, 2019)Cardiovascular disease (CVD) is a leading cause of worldwide deaths. A number of risk factors for cardiovascular disease as well as type 2 diabetes and stroke present as the metabolic syndrome. Metabolic risk factors include ... -
Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
(BMC (part of Springer Nature), 2019-06-04)Background: The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic ... -
Dietary impact on neuronal autophagy control and brain health
(IntechOpen, 2019)Autophagy is the major intracellular system which is critical for the removal of harmful protein aggregates and malfunctioning organelles. Dysfunctional autophagy is associated with a multitude of human diseases, such ... -
Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment
(Frontiers Media, 2018-12-11)Excess adipose tissue is a hallmark of an overweight and/or obese state as well as a primary risk factor for breast cancer development and progression. In an overweight/obese state adipose tissue becomes dysfunctional due ... -
C-reactive protein is elevated only in high creatine kinase responders to muscle damaging exercise
(Frontiers Media, 2017-02-11)The purpose of this study was to investigate if exertional rhabdomyolysis induced by an acute bout of plyometric exercise in untrained individuals was associated with histological characteristics of skeletal muscle, creatine ... -
The role of Gingko biloba extract on autophagy modulation, protein clearance and neuronal cell death in an in vitro model of Alzheimer's disease
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Introduction: Alzheimer’s disease (AD) is a complex neurological disease, characterized by two protein aggregate forms, namely extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary ... -
Neuromuscular junction endplate morphology, acetylcholine receptor aggregation and accessory protein co-localisation during regeneration of a skeletal muscle crush injury
(Stellenbosch : Stellenbosch University, 2019-02)ENGLISH ABSTRACT: At the neuromuscular junction (NMJ), peripheral nerves innervate the skeletal muscle to relay neural transmission. The acetylcholine receptors (AChRs) are located on the post-synaptic membrane and ...
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