Reyskens, Kathleen M. S. E.Fisher, Tarryn-LeeSchisler, Jonathan C.O'Connor, Wendi G.Rogers, Arlin B.Willis, Monte S.Planesse, CynthiaBoyer, FlorenceRondeau, PhilippeBourdon, EmmanuelEssop, M. F.(PLoS, 2013-11)
Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term side effects may include the onset of insulin resistance and cardiovascular diseases. However, the underlying molecular mechanisms responsible ...
Reyskens, Kathleen Maria Simone Elise(Stellenbosch : Stellenbosch University, 2013-12)
ENGLISH ABSTRACT: Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term effects include onset of insulin resistance and cardiovascular diseases. Increased oxidative stress and dysregulation ...
Loos, BenEngelbrecht, Anna-MartLockshin, Richard A.Klionsky, Daniel J.Zakeri, Zahra(Landes Bioscience, 2013-09)
Impaired autophagic machinery is implicated in a number of diseases such as heart disease, neurodegeneration and cancer. A common denominator in these pathologies is a dysregulation of autophagy that has been linked to a ...
Wlodzimirow, K. A.Eslami, S.Chamuleau, R. A. F. M.Nieuwoudt, M.Abu-Hanna, A.(PLOS, 2012-12-14)
Introduction: Acute liver failure is a rare disease with high mortality and liver transplantation is the only life saving therapy.
Accurate prognosis of ALF is crucial for proper intervention.
Aim: To identify and ...
ENGLISH ABSTRACT: Contusion injuries cause significant muscle damage, activating a series of cellular events. Satellite cells (SC), the key role players in muscle regeneration, are activated to proliferate and develop into ...
ENGLISH ABSTRACT: Introduction
Cisplatin has been widely used to treat solid tumours and much success has come from the use of this drug in the treatment of head and neck, ovarian, testicular, cervical and small-cell lung ...
ENGLISH ABSTRACT: Introduction:
Among the cancers that afflict females world-wide, neoplastic disease of breast tissue is the most frequently diagnosed form and the leading cause of cancer-related death. Conventional ...
ENGLISH ABSTRACT: Introduction: Breast cancer is a major contributor to mortality in women worldwide. Although, anthracyclines, such as doxorubicin, are among the most valuable treatments for breast cancer, their clinical ...
ENGLISH ABSTRACT: Introduction
Diabetes constitutes a major health challenge. Since cardiovascular complications are common in
diabetic patients this will further increase the overall burden of disease. Furthermore, ...
Le Roux, Heloise(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Introduction: Cancer is an emerging health problem in South Africa, with breast cancer being one of the leading cancers affecting women globally. Therefore, there is a need to find novel targets to improve ...
ENGLISH ABSTRACT: Context: There are serious deficiencies in the current tests and criteria available for the diagnosis of diabetes. A novel screening method for the earlier and more efficient detection of type 2 diabetes ...
Background: While Selection of reverse transcriptase (RT) mutation has been
reported frequently, protease (PR) mutations on antiretroviral therapy (ART) including
boosted Protease inhibitor (PI) have not been reported ...
ENGLISH ABSTRACT: The main aim of this workpiece was to establish the physiological parameters against which a vitamin
Bu deficiency could be measured. A comparison between the hematological values of healthy patients ...
ENGLISH ABSTRACT: The aim of this study was to investigate the influence of the allergic reaction on the
respiratory system. The influence of parasite infestation (with specific reference to
the roundworm, Ascaris ...
ENGLISH ABSTRACT: Introduction
Cardiovascular disease is one of the leading causes of death in the world.
Formation of harmful reactive oxygen species (ROS) is associated with
several pathological conditions, and ...
Kruger, Maria Jacoba(Stellenbosch : Stellenbosch University, 2007-12)
ENGLISH ABSTRACT: Human studies on the response of muscle to contusion injury are limited,
probably due to the large variability in injury severity and the non-specificity of
clinical symptoms reported. To circumvent ...
ENGLISH ABSTRACT: Gene expression of the cardiac isoform of acetyl-CoA carboxylase (ACCb) is induced
in a glucose-dependent manner. ACCb produces malonyl-CoA, a potent inhibitor of
mitochondrial fatty acid uptake. Previous ...
ENGLISH ABSTRACT: The aim of the study was to investigate skeletal muscle changes induced by an acute
bout of plyometric exercise before and after plyometric training. The study consisted of
an acute study and training ...
ENGLISH ABSTRACT: The human body has developed an integrated antioxidant defence system to protect
against free radical damage. Acute exercise may result in the increased generation of free
radicals, including reactive ...