Department of Physiological Sciences
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A possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura : results from a pilot study
(Frontiers Media, 2019-11-26)Introduction: Migraine is a debilitating primary headache disorder with a poorly understood aetiology. An extensive body of literature supports the theory of migraine as a systemic vascular inflammatory disorder characterised ... -
The impact of sugar-sweetened beverage intake on rat cardiac function
(Elsevier, 2019-03-12)Aims: Although there is evidence linking sugar-sweetened beverage (SSB) intake with the development of cardio-metabolic diseases, the underlying mechanisms remain unclear. The current study therefore evaluated the effects ... -
Bacterial dysbiosis and translocation in psoriasis vulgaris
(Frontiers Media, 2019-02-04)Psoriasis vulgaris is a chronic inflammatory skin condition, associated with both a physical and a psychological burden. Our understanding of the etiology of this disease remains incomplete. Conventionally, psoriasis has ... -
The impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysis
(MDPI, 2020)Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this ... -
The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells
(Springer Nature, 2019-01-28)Rhabdomyosarcoma (RMS) forms in skeletal muscle and is the most common soft tissue sarcoma in children and adolescents. Current treatment is associated with debilitating side effects and treatment outcomes for patients ... -
Effects of redox disturbances on motility, contractility and muscle tissue pathogenesis
(Hindawi, 2019-06-16)Whether in health or disease, reactive oxygen and nitrogen species (ROS/RNS) affect smooth and striated muscle status and function in ways not always discernible or appreciated. Despite the technological and methodological ... -
The cellular response of triple-negative breast cancer to short-term starvation: implications for chemosensitivity
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Introduction: Breast cancer is currently the most common cancer among women globally. Triplenegative breast cancer (TNBC) is an aggressive and often drug-resistant sub-type of breast cancer that is ... -
An investigation into the role of Serum Amyloid A in breast cancer
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Cancer remains a global challenge that affects many lives. To this extent, much research has gone into understanding this disease and the factors that contribute to it. Over the past 40 years, an ... -
Establishing and validating an unpredictable chronic mild stress rat model in a South African laboratory
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: There is growing concern regarding the societal implications of the increasing burden of chronic stress. In light of this, there are countless animal studies that are currently pursuing the underlying ... -
An evaluation of the role of platelet activation in HIV-related cardiovascular diseases onset
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Background: Although combined anti-retroviral treatment (cART) lowered HIV-AIDS onset, HIVpositive individuals display increased cardiovascular disease (CVD) onset. Enhanced myocardial fibrosis has ... -
Identification of potential biomarkers of cardiotoxicity induced by doxorubicin therapy in a tumour bearing model by targeting specific micro-RNAs
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Introduction: Anthracycline-induced cardiotoxicity, a major side effect of chemotherapeutic drugs such as doxorubicin (DOX), has been a priority within the field of cardio-oncology for a number of decades. ... -
Chronic stress-associated accelerated ageing: inflammation and oxidative stress treatment
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH ABSTRACT: In recent years, the incidence of non-communicable diseases (NCD) normally associated with advanced age has begun presenting in younger populations. This has resulted in a growing burden on global healthcare ... -
Amino acid starvation sensitizes resistant breast cancer to doxorubicin-induced cell death
(Frontiers Media, 2020)Many clinical trials are beginning to assess the effectiveness of compounds known to regulate autophagy in patients receiving anti-cancer chemotherapy. However, autophagy inhibition, through exogenous inhibitors, or ... -
The trace aminergic system : a gender-sensitive therapeutic target for IBS?
(BioMed Central, 2020-09-28)Due to a lack of specific or sensitive biomarkers, drug discovery advances have been limited for individuals suffering from irritable bowel syndrome (IBS). While current therapies provide symptomatic relief, inflammation ... -
Covid-19 : the rollercoaster of fibrin(ogen), D-dimer, Von Willebrand Factor, P-selectin and their interactions with endothelial cells, platelets and erythrocytes
(MDPI, 2020-07-21)Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus disease 2019 (COVID-19)-induced infection, is strongly associated with various coagulopathies that may result in either bleeding and ... -
Prevalence of amyloid blood clots in COVID-19 plasma
(medRxiv, 2020)The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the ... -
Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability
(Nature Research (part of Springer Nature), 2020-05-29)Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such ‘leaky gut’ conditions ... -
Comparison of pathological clotting using haematological, functional and morphological investigations in HIV-positive and HIV-negative patients with deep vein thrombosis
(BioMed Central, 2020-06-22)Background: Patients infected with the human immunodeficiency virus (HIV) are more prone to systemic inflammation and pathological clotting, and many may develop deep vein thrombosis (DVT) as a result of this dysregulat ... -
Decreased efficacy of doxorubicin corresponds with modifications in lipid metabolism markers and fatty acid profiles in breast tumors from obese vs. lean mice
(Frontiers Media, 2018-03-17)Breast cancer cells modulate lipid and fatty acid metabolism to sustain proliferation. The role of adipocytes in cancer treatment efficacy remains, however, to be fully elucidated. We investigated whether diet-induced ... -
Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics
(Nature Research, 2018-07-09)Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation ...
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