• Treading the tightrope of healthy living : pondering heart metabolism's balancing act 

  Essop, Faadiel (Stellenbosch : Stellenbosch University, 2011-09)

  Prof Faadiel Essop is the current chairperson of the Depart - ment of Physiological Sciences at Stellenbosch University. He hails from a strong rural background; he was born in Ceres and grew up in Paarl (Western Cape, ...
• The secret of dying well : the many faces of cell death and its relevance for treating diseases of our time 

  Engelbrecht, Anna-Mart (Stellenbosch : Stellenbosch University, 2014-03)

  Anna-Mart Engelbrecht is currently professor in the Department of Physiological Sciences at Stellenbosch University. She was born in Pretoria, grew up in the Western Cape and matriculated from DF Malan High School in ...
• The effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the non-oxidative pathways of glucose metabolism 

  Fisher, Tarryn-Lee (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: While antiretroviral therapy decreases HIV/AIDS morbidity and mortality, long-term treatment results in insulin resistance and cardiovascular diseases. A possible cause of such adverse effects may be an ...
• Hyperglycemia-mediated onset of myocardial insulin resistance – unraveling molecular mechanisms and identifying therapeutic targets 

  Joseph, Danzil Eugene (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Background - Although acute hyperglycemic episodes are linked to lower glucose uptake, underlying mechanisms driving this process remain unclear. We hypothesized that acute hyperglycemia triggers reactive ...
• Elucidating the underlying mechanisms of benfotiamine-induced cardioprotection 

  Garson, Kirsty-Lee (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Context: Cardiovascular diseases are the leading cause of death globally. Myocardial infarction is responsible for the highest number of deaths due to cardiovascular disease. Objective: We have previously ...
• Cardio-metabolic effects of HIV protease inhibitors (Lopinavir/Ritonavir) 

  Reyskens, Kathleen M. S. E.   Fisher, Tarryn-Lee   Schisler, Jonathan C.   O'Connor, Wendi G.   Rogers, Arlin B.   Willis, Monte S.   Planesse, Cynthia   Boyer, Florence   Rondeau, Philippe   Bourdon, Emmanuel   Essop, M. F. (PLoS, 2013-11)

  Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term side effects may include the onset of insulin resistance and cardiovascular diseases. However, the underlying molecular mechanisms responsible ...
• The maladaptive effects of HIV protease inhibitors (Lopinavir/Ritonavir) on the rat heart. 

  Reyskens, Kathleen Maria Simone Elise (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term effects include onset of insulin resistance and cardiovascular diseases. Increased oxidative stress and dysregulation ...
• The variability of autophagy and cell death susceptibility : unanswered questions 

  Loos, Ben   Engelbrecht, Anna-Mart   Lockshin, Richard A.   Klionsky, Daniel J.   Zakeri, Zahra (Landes Bioscience, 2013-09)

  Impaired autophagic machinery is implicated in a number of diseases such as heart disease, neurodegeneration and cancer. A common denominator in these pathologies is a dysregulation of autophagy that has been linked to a ...
• Prediction of poor outcome in patients with acute liver failure—systematic review of prediction models 

  Wlodzimirow, K. A.   Eslami, S.   Chamuleau, R. A. F. M.   Nieuwoudt, M.   Abu-Hanna, A. (PLOS, 2012-12-14)

  Introduction: Acute liver failure is a rare disease with high mortality and liver transplantation is the only life saving therapy. Accurate prognosis of ALF is crucial for proper intervention. Aim: To identify and ...
• Grape seed extract affects adhesion competence and maturation of primary isolated rat myoblasts after contusion injury 

  Engelbrecht, Lize (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Contusion injuries cause significant muscle damage, activating a series of cellular events. Satellite cells (SC), the key role players in muscle regeneration, are activated to proliferate and develop into ...
• Manipulation of the autophagic pathway sensitises cervical cancer cells to cisplatin treatment 

  Leisching, Gina Renata (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Introduction Cisplatin has been widely used to treat solid tumours and much success has come from the use of this drug in the treatment of head and neck, ovarian, testicular, cervical and small-cell lung ...
• The relationship between HIF-1α and autophagy activity in the hypoxic environment of breast cancer 

  Mills, Justin (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Introduction: Among the cancers that afflict females world-wide, neoplastic disease of breast tissue is the most frequently diagnosed form and the leading cause of cancer-related death. Conventional ...
• The role of short-term starvation in sensitizing breast cancer to chemotherapy 

  Govender, Yogeshni (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Introduction: Breast cancer is a major contributor to mortality in women worldwide. Although, anthracyclines, such as doxorubicin, are among the most valuable treatments for breast cancer, their clinical ...
• The hexosamine biosynthetic pathway induces gene promoter activity of the cardiac-enriched isoform of acetyl-CoA carboxylase 

  Imbriolo, Jamie (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: The cardiac isoform of acetyl-CoA carboxylase (ACCβ) produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid (FA) uptake; thus increased ACCβ activity decreases fatty acid utilization thereby ...
• Novel therapeutic agents that blunt hyperglycemia-induced cardiac contractile dysfunction 

  Mapanga, Rudo Fiona (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Introduction Diabetes constitutes a major health challenge. Since cardiovascular complications are common in diabetic patients this will further increase the overall burden of disease. Furthermore, ...
• The contribution of inflammatory mediators to delayed secondary muscle damage 

  Van de Vyver, Mari (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Background: Understanding the contribution of divergent individual response patterns remains a key objective in identifying mechanisms of inflammation and potential factors limiting the resolution of ...
• The effect of MKP-1 inhibition on the cytotoxicity of chemotherapeutic drugs in breast cancer 

  Le Roux, Heloise (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Introduction: Cancer is an emerging health problem in South Africa, with breast cancer being one of the leading cancers affecting women globally. Therefore, there is a need to find novel targets to improve ...
• Leukocyte O-GlcNAcylation : a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus? 

  Springhorn, Clare (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Context: There are serious deficiencies in the current tests and criteria available for the diagnosis of diabetes. A novel screening method for the earlier and more efficient detection of type 2 diabetes ...
• Predictive value of gene mutations as a diagnostic tool for ART resistance in a Zambian population 

  Maseko Phiri, Thabiso (Stellenbosch : Stellenbosch University, 2012-12)

  Background: While Selection of reverse transcriptase (RT) mutation has been reported frequently, protease (PR) mutations on antiretroviral therapy (ART) including boosted Protease inhibitor (PI) have not been reported ...
• The physiological effect of vitamin B12 deficiency in human blood 

  Abel, Stefan (Stellenbosch : Stellenbosch University, 1990-11)

  ENGLISH ABSTRACT: The main aim of this workpiece was to establish the physiological parameters against which a vitamin Bu deficiency could be measured. A comparison between the hematological values of healthy patients ...

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