Department of Physiological Sciences
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In vitro induction of quiescence in isolated primary human myoblasts
(Springer Nature, 2020-01-28)Adult skeletal muscle stem cells, satellite cells, remain in an inactive or quiescent state in vivo under physiological conditions. Progression through the cell cycle, including activation of quiescent cells, is a tightly ... -
Insulin as an immunomodulatory hormone
(Elsevier, 2019)Insulin plays an indispensable role in the management of hyperglycaemia that arises in a variety of settings, including Type I and II diabetes, gestational diabetes, as well as is in hyperglycaemia following a severe ... -
Serum amyloid A and inflammasome activation : a link to breast cancer progression?
(Elsevier, 2020-10-27)Breast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which ... -
Investigations into the cytotoxic mechanism of action for the garlic compound ajoene and its derivatives in breast cancer cells
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Breast cancer continues to place a severe burden on women globally. There has been a growing interest in natural compounds for cancer prevention, with several phytochemicals possessing anti-cancer ... -
The role of Serum Amyloid A in NLRP3 inflammasome signalling in breast and colon cancer
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Introduction: Cancer is a complex disease with multiple interactions targeting the organism on cellular, tissue and systemic levels. The main research focus for the past decades has been on the genome ... -
Molecular regulation of autophagy and metastasis in breast cancer: new insights into the role of serum amyloid A
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Introduction: Cytokines, growth factors and acute phase proteins present in the tumour microenvironment regulate inflammatory responses and alter crosstalk between various signalling pathways involved ... -
Intercellular communication between macrophages, myoblasts and fibroblasts in the context of rheumatoid arthritis-associated skeletal muscle wasting
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH ABSTRACT: Approximately 1% of the global population is afflicted with rheumatoid arthritis (RA), of which over a third experience rheumatoid cachexia, a RA-specific form of skeletal muscle wasting. Current patient ... -
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation
(Nature Research (part of Springer Nature), 2019-02-28)Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid ... -
Small extracellular vesicle dynamics and microRNA cargo in response to gradient specific high intensity running
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Skeletal muscle adaptation in response to exercise is a highly dynamic process and small extracellular vesicles (EVs) (30-150 nm) are postulated to be mediators of intercellular communication during ... -
Parkinson’s disease : a systemic inflammatory disease accompanied by bacterial inflammagens
(Frontiers Media, 2019-08-27)Parkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipain protease group from Porphyromonas gingivalis was ... -
A possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura : results from a pilot study
(Frontiers Media, 2019-11-26)Introduction: Migraine is a debilitating primary headache disorder with a poorly understood aetiology. An extensive body of literature supports the theory of migraine as a systemic vascular inflammatory disorder characterised ... -
The impact of sugar-sweetened beverage intake on rat cardiac function
(Elsevier, 2019-03-12)Aims: Although there is evidence linking sugar-sweetened beverage (SSB) intake with the development of cardio-metabolic diseases, the underlying mechanisms remain unclear. The current study therefore evaluated the effects ... -
The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells
(Elsevier, 2019)Breast cancer is frequently diagnosed in women and poses a major health problem throughout the world. Currently, the unresponsiveness of cancer cells to chemotherapeutics is a major concern. During chemotherapeutic treatment ... -
Bacterial dysbiosis and translocation in psoriasis vulgaris
(Frontiers Media, 2019-02-04)Psoriasis vulgaris is a chronic inflammatory skin condition, associated with both a physical and a psychological burden. Our understanding of the etiology of this disease remains incomplete. Conventionally, psoriasis has ... -
The impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysis
(MDPI, 2020)Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this ... -
The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells
(Springer Nature, 2019-01-28)Rhabdomyosarcoma (RMS) forms in skeletal muscle and is the most common soft tissue sarcoma in children and adolescents. Current treatment is associated with debilitating side effects and treatment outcomes for patients ... -
A combination of an antimitotic and a bromodomain 4 inhibitor synergistically inhibits the metastatic MDA-MB-231 breast cancer cell line
(Hindawi Publishing, 2019-12-11)Current chemotherapeutic agents have many side effects and are toxic to normal cells, providing impetus to identify agents that can effectively eliminate tumorigenic cells without damaging healthy cells. The aim of this ... -
Anxiety : an overlooked confounder in the characterisation of chronic stress-related conditions?
(Public Library of Science, 2020-04-16)Although anxiety disorders are among the most prevalent of psychiatric disorders, childhood trauma-related studies seldom consider anxiety proneness as distinct aetiological contributor. We aimed to distinguish between ... -
Effects of redox disturbances on motility, contractility and muscle tissue pathogenesis
(Hindawi, 2019-06-16)Whether in health or disease, reactive oxygen and nitrogen species (ROS/RNS) affect smooth and striated muscle status and function in ways not always discernible or appreciated. Despite the technological and methodological ... -
Investigating aberrant DNA methylation patterns in LOXL2 as a potential predictor of diabetes-induced cardiac dysfunction
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with 17.9 million deaths annually. CVD pathophysiology is often characterized by increased stiffening of the heart muscle ...
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