HbA1c of 6.5% to diagnose Diabetes Mellitus—Does it work for Us?—The Bellville South Africa study

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dc.contributor.author Zemlin, Annalise E.
dc.contributor.author Matsha, Tandi E.
dc.contributor.author Hassan, Mogamat S.
dc.contributor.author Erasmus, Rajiv T.
dc.date.accessioned 2012-07-30T12:43:15Z
dc.date.available 2012-07-30T12:43:15Z
dc.date.issued 2011-08
dc.identifier.citation Zemlin, A. E., Matsha, T. E., Hassan, M. S. & Erasmus, R.T. 2011. HbA1c of 6.5% to diagnose Diabetes Mellitus—Does It Work for Us?—The Bellville South Africa Study. PLoS ONE, 6(8), e22558, doi:10.1371/journal.pone.0022558. en_ZA
dc.identifier.issn 1932-6203 (online)
dc.identifier.other doi:10.1371/journal.pone.0022558
dc.identifier.uri http://hdl.handle.net/10019.1/21882
dc.description The original publication is available at http:/www.plosone.org en_ZA
dc.description Bibliography
dc.description.abstract Background: HbA1c has been the gold standard for glycaemic control follow-up for decades. In 2009, a level of 6.5% (48 mmol/mol) was proposed as diagnostic for diabetes. We test this cut-off in our community. Methods: Participants (946) from a community-based study were screened for diabetes using either a fasting blood glucose or oral glucose tolerance test (OFTT). The HbA1c cut-off of 6.5% was tested for each group. A receiver operator characteristic (ROC) curve for both groups was generated to establish an optimal cut-off. Results: Our study included 224 (23.7%) males and 722 (76.3%) females. Using fasting blood glucose alone, 117 (14%) were diagnosed with diabetes 250% had an HbA1c value of $6.5% (48 mmol/mol). Using an OGTT, 147 (18%) were diagnosed with diabetes 246% had an HbA1c value of $6.5% (48 mmol/mol). ROC curves found a level of 6.1% (43 mmol/mol) to be optimal in both groups (AUC 0.85 and 0.82 respectively). The sensitivities were 80% and 75% and the specificities 77% and 78% respectively. Conclusions: A cut off of 6.5% (48 mmol/mol) is a good diagnostic tool with its high specificity; however the low sensitivity limits its use. We found a level of 6.1% (43 mmol/mol) to be optimal. This emphasizes the need for evidenced based values to be established in various population groups. en_ZA
dc.description.sponsorship National Health Laboratory Services of South Africa
dc.description.sponsorship University Research Fund of the Cape Peninsula University of Technology
dc.format.extent 4 p. : ill.
dc.language.iso en_ZA en_ZA
dc.publisher Public Library of Science (PLOS) en_ZA
dc.subject Diabetes mellitus -- Effect of HbAlc on en_ZA
dc.subject Diabetes mellitus -- Diagnosis -- Western Cape -- Bellville -- Case study en_ZA
dc.subject Glycaemic control en_ZA
dc.subject Diabetes mellitus -- Treatment -- Western Cape -- Bellville -- Case studies en_ZA
dc.subject.lcsh Medical laboratory diagnosis en_ZA
dc.title HbA1c of 6.5% to diagnose Diabetes Mellitus—Does it work for Us?—The Bellville South Africa study en_ZA
dc.type Article en_ZA
dc.description.version Publishers' Version en_ZA
dc.rights.holder Authors retain the copyright en_ZA


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