HbA1c of 6.5% to diagnose Diabetes Mellitus—Does it work for Us?—The Bellville South Africa study

dc.contributor.authorZemlin, Annalise E.
dc.contributor.authorMatsha, Tandi E.
dc.contributor.authorHassan, Mogamat S.
dc.contributor.authorErasmus, Rajiv T.
dc.identifier.citationZemlin, A. E., Matsha, T. E., Hassan, M. S. & Erasmus, R.T. 2011. HbA1c of 6.5% to diagnose Diabetes Mellitus—Does It Work for Us?—The Bellville South Africa Study. PLoS ONE, 6(8), e22558, doi:10.1371/journal.pone.0022558.en_ZA
dc.identifier.issn1932-6203 (online)
dc.descriptionThe original publication is available at http:/www.plosone.orgen_ZA
dc.description.abstractBackground: HbA1c has been the gold standard for glycaemic control follow-up for decades. In 2009, a level of 6.5% (48 mmol/mol) was proposed as diagnostic for diabetes. We test this cut-off in our community. Methods: Participants (946) from a community-based study were screened for diabetes using either a fasting blood glucose or oral glucose tolerance test (OFTT). The HbA1c cut-off of 6.5% was tested for each group. A receiver operator characteristic (ROC) curve for both groups was generated to establish an optimal cut-off. Results: Our study included 224 (23.7%) males and 722 (76.3%) females. Using fasting blood glucose alone, 117 (14%) were diagnosed with diabetes 250% had an HbA1c value of $6.5% (48 mmol/mol). Using an OGTT, 147 (18%) were diagnosed with diabetes 246% had an HbA1c value of $6.5% (48 mmol/mol). ROC curves found a level of 6.1% (43 mmol/mol) to be optimal in both groups (AUC 0.85 and 0.82 respectively). The sensitivities were 80% and 75% and the specificities 77% and 78% respectively. Conclusions: A cut off of 6.5% (48 mmol/mol) is a good diagnostic tool with its high specificity; however the low sensitivity limits its use. We found a level of 6.1% (43 mmol/mol) to be optimal. This emphasizes the need for evidenced based values to be established in various population groups.en_ZA
dc.description.sponsorshipNational Health Laboratory Services of South Africa
dc.description.sponsorshipUniversity Research Fund of the Cape Peninsula University of Technology
dc.format.extent4 p. : ill.
dc.publisherPublic Library of Science (PLOS)en_ZA
dc.subjectDiabetes mellitus -- Effect of HbAlc onen_ZA
dc.subjectDiabetes mellitus -- Diagnosis -- Western Cape -- Bellville -- Case studyen_ZA
dc.subjectGlycaemic controlen_ZA
dc.subjectDiabetes mellitus -- Treatment -- Western Cape -- Bellville -- Case studiesen_ZA
dc.subject.lcshMedical laboratory diagnosisen_ZA
dc.titleHbA1c of 6.5% to diagnose Diabetes Mellitus—Does it work for Us?—The Bellville South Africa studyen_ZA
dc.description.versionPublishers' Versionen_ZA
dc.rights.holderAuthors retain the copyrighten_ZA

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