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Principles of intravenous drug infusion

dc.contributor.authorCoetzee J.F.
dc.date.accessioned2012-05-17T08:14:42Z
dc.date.available2012-05-17T08:14:42Z
dc.date.issued2012
dc.identifier.citationAnaesthesia and Intensive Care Medicine
dc.identifier.citation13
dc.identifier.citation5
dc.identifier.citation243
dc.identifier.citation246
dc.identifier.issn14720299
dc.identifier.other10.1016/j.mpaic.2012.02.011
dc.identifier.urihttp://hdl.handle.net/10019.1/21007
dc.description.abstractIt is possible to establish and maintain targeted blood and effect-site drug concentrations with reasonable accuracy using a 'bolus, elimination, transfer' (BET) infusion regimen. Simulation software that employs pharmacokinetic models can be used to drive infusion pumps or to design manually-controlled BET infusions. Prolonged infusions can result in prolonged recovery times. However the elimination half-lives of infused lipid soluble drugs have little or no relevance to rates of recovery because elimination half-life does not take redistribution from peripheral compartments into account. A better method is to calculate the context-sensitive decrement times (context-sensitive referring to the infusion duration). These are not represented by a single number: they are a continuum of time values that are a function of infusion duration and can be represented by a graph. Considering that decrement times depend on the concentrations achieved as well as the dose history, it is often difficult for clinicians to anticipate a patient's time to recovery. Pharmacokinetic simulation software continuously calculates and displays expected recovery times, helping clinicians to ascertain when to reduce or terminate the infusion. © 2012 Published by Elsevier Ltd.
dc.titlePrinciples of intravenous drug infusion
dc.typeArticle


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