SUNScholar
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Faculty of AgriSciences
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Department of Genetics
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Now showing items 1-8 of 8

Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis : a case-control association study

Moller, Marlo Nebel, Almut Van Helden, Paul D. Schreiber, Stefan Hoal, Eileen G. (BioMed Central, 2010-06)

Background: Interferon gamma is a major macrophage-activating cytokine during infection with Mycobacterium tuberculosis, the causative pathogen of tuberculosis, and its role has been well established in animal models and ...
Functional analysis of the 5' regulatory region of the 5-aminolevulinate synthase(ALAS1) gene in response to estrogen

Du Plessis, N. Kimberg, M. Zaahl, M. G. Sadie, A. Venter, M. Van Der Merwe, L. Louw, Ann Warnich, L. (C.M.B. Association, 2009-07)

Genetic defects in the heme synthesis enzymes lead to a group of heterogeneous disorders termed the porphyrias. Numerous factors influence the clinical expression of porphyrias, primarily by altering the rate of heme ...
Next-generation sequencing of cervical DNA detects human papillomavirus types not detected by commercial kits

Meiring, Tracy L Salimo, Anna T Coetzee, Beatrix Maree, Hans J Moodley, Jennifer Hitzeroth, Inga I Freeborough, Michael-John Rybicki, Ed P. Williamson, Anna-Lise (BioMed Central, 2012-08)

Abstract Background Human papillomavirus (HPV) is the aetiological agent for cervical cancer and genital warts. Concurrent HPV and HIV infection in the South African population is high. HIV ...
Pharmacogenomic research in South Africa : lessons learned and future opportunities in the rainbow nation

Warnich, Louise Drogemoller, Britt I. Pepper, Michael S. Dandara, Collet Wright, Galen E.B. (Bentham Science, 2011-09)

ENGLISH ABSTRACT: South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This ...
Predicting mortality and length-of-stay for neonatal admissions to private hospital neonatal intensive care units : a Southern African retrospective study

Pepler, Pieter Theo Uys, Daniel Wilhelm Nel, Daniel Gerhardus (Faculty of Medicine, Makerere University, 2012-06)

Objectives: To predict neonatal mortality and length of stay (LOS) from readily available perinatal data for neonatal intensive care unit (NICU) admissions in Southern African private hospitals. Methods: Retrospective ...
Real-time RT-PCR high resolution melting curve analysis and multiplex RT-PCR to detect and differentiate grapevine leafroll-associated associated virus 3 variant groups I, II, III and VI

Bester, Rachelle Jooste, Anna E. C. Maree, Hans J. Burger, Johan T. (BioMed Central, 2012-09)

Abstract Background Grapevine leafroll-associated virus 3 (GLRaV-3) is the main contributing agent of leafroll disease worldwide. Four of the six GLRaV-3 variant groups known have been found ...
Transcriptome characterization of the South African abalone Haliotis midae using sequencing-by-synthesis

Franchini, Paolo Van der Merwe, Mathilde Roodt-Wilding, Rouvay (BioMed Central, 2011-03)

Abstract. Background. Worldwide, the genus Haliotis is represented by 56 extant species and several of these are commercially cultured. Among the six abalone species found in South Africa, Haliotis midae is the only ...
Visualization of plant viral suppressor silencing activity in intact leaf lamina by quantitative fluorescent imaging

Stephan, Dirk Slabber, Coba George, Gavin Ninov, Victor Francis, Kevin P. Burger, Johan T. (BioMed Central Ltd., 2011-08)

ABSTRACT: BACKGROUND: Transient expression of proteins in plants has become a favoured method over the production of stably transformed plants because, in addition to enabling high protein yields, it is both fast and easy ...