• Characterization of the genetic variation present in CYP3A4 in three South African populations 

      Drogemoller, Britt; Plummer, Marieth; Korkie, Lundi; Agenbag, Gloudi; Dunaiski, Anke; Niehaus, Dana; Koen, Liezl; Gebhardt, Stefan; Schneider, Nicol; Olckers, Antonel; Wright, Galen; Warnich, Louise (Frontiers, 2013-02)
      The CYP3A4 enzyme is the most abundant human cytochrome P450 (CYP) and is regarded as the most important enzyme involved in drug metabolism. Inter-individual and inter-population variability in gene expression and enzyme ...
    • Chromosome 22q11 in a Xhosa schizophrenia population 

      Koen, Liezl; Niehaus, Dana J. H.; Wright, Galen; Warnich, Louise; De Jong, Greetje; Emsley, Robin A.; Mall, Sumaya (Health and Medical Publishing Group (HMPG), 2012-03)
      Chromosome 22q11 aberrations substantially increase the risk for developing schizophrenia. Although micro-deletions in this region have been extensively investigated in different populations across the world, little is ...
    • Introduction of the AmpliChip CYP450 Test to a South African cohort : a platform comparative prospective cohort study 

      Dodgen, Tyren M.; Hochfeld, Warren E.; Fickl, Heidi; Asfaha, Sahle M.; Durandt, Chrisna; Rheeder, Paul; Drogemoller, Britt I.; Wright, Galen E. B.; Warnich, Louise; Labuschagne, Christiaan D. J.; Van Schalkwyk, Antoinette; Gaedigk, Andrea; Pepper, Michael S. (BioMed Central, 2013-01)
      Abstract Background Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability ...
    • Pharmacogenomic research in South Africa : lessons learned and future opportunities in the rainbow nation 

      Warnich, Louise; Drogemoller, Britt I.; Pepper, Michael S.; Dandara, Collet; Wright, Galen E.B. (Bentham Science, 2011-09)
      ENGLISH ABSTRACT: South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This ...