Neutral mononuclear and dinuclear complexes of gold(I) featuring azole ligands: Synthesis, structure and cytotoxicity

Gabrielli W.F. ; Nogai S.D. ; Nell M. ; Cronje S. ; Raubenheimer H.G. (2012)


The aim of this work was to extend the small library of existing compounds of gold(I) that contain pentafluorophenyl and thiazole ligands and to determine the biological activity of such compounds against a well-known cancer cell line. Seven mono and dinuclear new compounds that contain imidazole, thiazole and tetrazole rings were isolated and characterised. Three of the crystal structures determined indicated Au...Au interactions between constituent complex molecules. A simple adduct, [Au(C 6F 5)(N-methyl-imidazole)] , exhibits a relatively high anti-tumour specificity indicating the viability of selected phosphine-free gold complexes as cytotoxic agents. © 2012 Elsevier Ltd. All rights reserved.

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