Inositol phosphoglycan P-type in infants of preeclamptic mothers

Scioscia M. ; Robillard P.-Y. ; Hall D.R. ; Rademacher L.H. ; Williams P.J. ; Rademacher T.W. (2012)


Background. Inositol phosphoglycan P-type (P-IPG) has consistently found to be elevated during active preeclampsia, although the biosynthetic source has to be identified yet. This multicenter prospective cross-sectional case-control study evaluated the fetus/newborn as the source of P-IPG. Methods. A urine specimen was collected longitudinally for three consecutive days after delivery from 90 newborns and their mothers, and ordered according to clinical diagnosis of preeclampsia, gestational hypertension, or healthy pregnancy. Results. The urinary excretion of P-IPG on day 0 was higher in the mothers in all groups (p<0.05) with higher levels in preeclamptic women (p<0.01) in the mothers compared to their newborns in the preeclamptic group (p<0.01). The difference persisted at least two days post partum. Conclusion. Findings of this study confirm the specificity of the increase in urinary excretion of P-IPG in preeclamptic mothers at day of birth compared to healthy pregnancy and GH, but does not extend to their newborns. © 2012 Informa UK, Ltd.

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