Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6

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dc.contributor.author Smith, C.
dc.contributor.author Wilson, N. W.
dc.contributor.author Louw, Ann
dc.contributor.author Myburgh, K. H.
dc.date.accessioned 2012-02-09T14:41:02Z
dc.date.issued 2006-12
dc.identifier.citation Smith, C., Wilson, N. W., Louw, A. & Myburgh, K. H. 2006. Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 292(--),1439-1447, doi:10.1152/ajpregu.00602.2006. en_ZA
dc.identifier.issn 1522-1490 (online)
dc.identifier.issn 0363-6119 (print)
dc.identifier.other doi:10.1152/ajpregu.00602.2006
dc.identifier.uri http://hdl.handle.net/10019.1/19689
dc.description The original publication is available at http://www.ajpregu.org en_ZA
dc.description.abstract ACUTE PSYCHOLOGICAL STRESS is known to activate the hypothalamic- pituitary-adrenal (HPA) axis, resulting in transiently increased release of inflammatory cytokines (28) and glucocorticoids (45). In contrast, multiple exposures to stress lead to adaptive responses in target tissues such as liver, skeletal muscle, and immune cells. These responses may be influenced by the severity of the stressor and the duration of the stress exposure. The endocrine and cytokine responses are known to be interrelated but are complex and still incompletely understood. en_ZA
dc.format.extent p. R1439-R1447 : ill. en_ZA
dc.language.iso en_ZA en_ZA
dc.publisher American Physiological Society en_ZA
dc.subject Stress (Psychology) -- Testing en_ZA
dc.subject Glucocorticoid Receptors en_ZA
dc.subject Hypothalamic-pituitary-adrenal axis en_ZA
dc.subject Peripheral blood mononuclear cell function en_ZA
dc.title Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6 en_ZA
dc.type Article en_ZA
dc.description.version Publishers' Version en_ZA
dc.rights.holder American Physiological Society en_ZA


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