Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6
Date
2006-12
Authors
Smith, C.
Wilson, N. W.
Louw, Ann
Myburgh, K. H.
Journal Title
Journal ISSN
Volume Title
Publisher
American Physiological Society
Abstract
ACUTE PSYCHOLOGICAL STRESS is known to activate the hypothalamic-
pituitary-adrenal (HPA) axis, resulting in transiently increased
release of inflammatory cytokines (28) and glucocorticoids
(45). In contrast, multiple exposures to stress lead to adaptive
responses in target tissues such as liver, skeletal muscle, and
immune cells. These responses may be influenced by the severity
of the stressor and the duration of the stress exposure. The
endocrine and cytokine responses are known to be interrelated but
are complex and still incompletely understood.
Description
The original publication is available at http://www.ajpregu.org
Keywords
Stress (Psychology) -- Testing, Glucocorticoid Receptors, Hypothalamic-pituitary-adrenal axis, Peripheral blood mononuclear cell function
Citation
Smith, C., Wilson, N. W., Louw, A. & Myburgh, K. H. 2006. Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 292(--),1439-1447, doi:10.1152/ajpregu.00602.2006.