Not all progestins are the same : implications for usage

Date
2004-11
Authors
Hapgood, Janet P.
Koubovec, Dominique
Louw, Ann
Africander, Donita
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of action of the relatively nonspecific and most widely used synthetic progestins, medroxyprogesterone acetate and norethisterone, are discussed in the context of this recent clinical evidence. Future directions involving a more mechanism-based approach for improved therapeutics, with greater specificity and fewer side-effects, are discussed.
Description
The original publication is available at www.sciencedirect.com
Keywords
Progestational hormones -- Physiologcial effect, Progesterone -- Physiological effect, Contraceptives, Hormone replacement therapy
Citation
Hapgood, J. P., Koubovec, D. Louw, A. & Africander, D. 2004. Not all progestins are the same: implications for usage. Trends in pharmacological sciences, 25(11), 554-557, doi:10.1016/j.tips.2004.09.005